A Study To Compare The Amount Of Premarin Components That Is Absorbed Into The Blood Of Japanese Healthy Postmenopausal Women Following Oral Administration Of Two Different Tablets Of Premarin Under Fast and Fed Conditions.

NCT ID: NCT01436513

Last Updated: 2012-03-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

72 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-10-31

Study Completion Date

2012-03-31

Brief Summary

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The purpose of this study is to assess the bioequivalence and food effect for a new Premarin formulation compared with a Premarin reference tablet in Japanese healthy postmenopausal women.

Detailed Description

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Conditions

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Primary Ovarian Insufficiency Vaginitis Metrorrhagia Menopause

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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A

Premarin reference tablet as a single oral dose under fasted conditions

Group Type EXPERIMENTAL

Premarin reference tablet (fasted)

Intervention Type DRUG

Premarin reference tablet, single dose, fasted conditions

B

Premarin new tablet as a single oral dose under fasted conditions

Group Type EXPERIMENTAL

Premarin new tablet (fasted)

Intervention Type DRUG

Premarin new tablet, single dose, fasted conditions

C

Premarin reference tablet as a single oral dose under fed conditions

Group Type EXPERIMENTAL

Premarin reference tablet (fed)

Intervention Type DRUG

Premarin reference tablet, single dose, fed conditions

D

Premarin new tablet as a single oral dose under fed conditions

Group Type EXPERIMENTAL

Premarin new tablet (fed)

Intervention Type DRUG

Premarin new tablet, single dose, fed conditions

Interventions

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Premarin reference tablet (fasted)

Premarin reference tablet, single dose, fasted conditions

Intervention Type DRUG

Premarin new tablet (fasted)

Premarin new tablet, single dose, fasted conditions

Intervention Type DRUG

Premarin reference tablet (fed)

Premarin reference tablet, single dose, fed conditions

Intervention Type DRUG

Premarin new tablet (fed)

Premarin new tablet, single dose, fed conditions

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Japanese healthy postmenopausal women

Exclusion Criteria

* History or current evidence of thrombophlebitis, thromboembolic disorders, or any coagulopathies.
* History or presence of malignancy or estrogen-dependent neoplasia. Subjects with a documented history of any malignancy, except for basal or squamous cell carcinoma of skin, which has been treated and fully resolved for a minimal 5 years.
* History or presence of benign or malignant liver tumor that developed during the use of oral contraceptives or other estrogen-containing products.
Minimum Eligible Age

45 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Shinjyuku-ku, Tokyo, Japan

Site Status

Countries

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Japan

Related Links

Other Identifiers

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3117X3-1112

Identifier Type: -

Identifier Source: secondary_id

B2811002

Identifier Type: -

Identifier Source: org_study_id

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