Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
273 participants
OBSERVATIONAL
2010-11-30
2012-12-31
Brief Summary
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Detailed Description
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In Vietnam, S. suis infection in adults is common, and patients with S.suis are often admitted to the National Hospital for Tropical Diseases (NHTD), a tertiary referral hospital for infectious diseases in northern Vietnam. In 2007, 50 laboratory confirmed cases with S.suis were reported at this hospital, and in 2010, 65 laboratory confirmed S.suis cases have been identified by September. Pig breeding and pork consumption is popular in Vietnam, with the majority of pigs and meat supply channelled from small-scaled un-controlled farmers and slaughterhouses, which pose a great potential health risk to people involved in the chain. A case-control study conducted in southern Vietnam showed that occupational exposure, raising pigs at home and consuming high-risk dishes from pigs significantly increased the risk of S. suis infection.
It has been suggested that the incidence of human S. suis cases is possibly linked to the occurrence of Porcine Respiratory and Reproductive System (PRRS) virus outbreaks in northern Vietnam. In 2010, the disease has spread to over 30 provinces over the country, with many outbreaks reported in northern provinces in the period from April to July. Field observations in other countries showed that PRRS virus infection increased pig's susceptibility to S. suis infection, including serotype 2 and 7. Therefore, PRRS virus outbreaks might have increased the risk of S. suis transmission to humans through exposure to pigs with PRRS virus infection and concomitant S. suis disease. Nevertheless, sufficient data are not available to confirm or refute this hypothesis. Knowledge of spatial and temporal relationships between human S.suis infections and disease outbreaks in pigs can increase our understanding of risk factors for human S.suis infection and support disease prevention and preparedness in the community.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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S.suis cases
This group consists of human cases with S.suis infection (confirmed or probable) admitted to National Hospital for Tropical Diseases in 2010.
No interventions assigned to this group
Sepsis controls
This group consists of hospital controls diagnosed with sepsis (not caused by S.suis) admitted to National Hospital for Tropical Diseases in 2010.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* S.suis infection confirmed by either CSF or blood culture or PCR; or
* Meet the criteria for a probable case as above (in absence of laboratory confirmation).
* Diagnosis as sepsis at hospital admission (based on clinical symptoms or laboratory evidence)
* Admission date between 01/01/2010 and 31/12/2010
Exclusion Criteria
Group 2: controls
* Symptoms of meningitis
* Clinically a high suspicion of S. suis infection (culture and PCR negative) as determined by doctor.
* Laboratory culture or PCR result positive for S.suis infection
* HIV infection
* Unable to collect patient's spatial data at commune level
ALL
No
Sponsors
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National Hospital for Tropical Diseases, Hanoi, Vietnam
OTHER_GOV
Oxford University Clinical Research Unit, Vietnam
OTHER
Responsible Party
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Principal Investigators
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Kinh V Nguyen, PhD
Role: PRINCIPAL_INVESTIGATOR
National Hospital for Tropical Diseases
Heiman F Wertheim, PhD
Role: PRINCIPAL_INVESTIGATOR
Oxford University Clinical Research Unit - Hanoi
Locations
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National Hospital for Tropical Diseases
Hanoi, Hanoi, Vietnam
Countries
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Related Links
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Other Identifiers
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02ZN
Identifier Type: -
Identifier Source: org_study_id