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Progesterone on the Day of Ovulation Induction is Associated With Pregnancy Outcome

NCT ID: NCT01426152

Last Updated: 2011-08-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2555 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-01-31

Study Completion Date

2011-04-30

Brief Summary

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Progesterone levels measured in blood/serum of patients on the day of ovulation induction following controlled ovarian stimulation for in vitro fertilization may be associated with pregnancy outcome. The hypothesis is that higher progesterone levels are associated with lower implantation rates due to changes in the endometrial receptivity.

Detailed Description

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Conditions

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Female Infertility

Keywords

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IVF progesterone ovulation induction pregnancy rates Female Infertility Due to Nonimplantation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Low level progesterone group (1)

Progesterone \< 1.50 ng/mL on day of ovulation induction

No interventions assigned to this group

Medium level progesterone group (2)

Progesterone 1.51-1.99 ng/mL on the day of ovulation induction

No interventions assigned to this group

High level progesterone group (3)

Progesterone \> 1.99 ng/mL on the day of ovulation induction

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* IVF/ICSI following controlled ovarian stimulation
* progesterone measured on the day of ovulation induction
* informed consent

Exclusion Criteria

* missing consent
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Bollmann Bruckner Noss

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Robert Ochsenkuehn, MD

Role: PRINCIPAL_INVESTIGATOR

Center for Reproductive Medicine

Locations

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Praxis Bollmann-Brückner-Noss

Munich, Bavaria, Germany

Site Status

Countries

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Germany

References

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Ochsenkuhn R, Arzberger A, von Schonfeldt V, Gallwas J, Rogenhofer N, Crispin A, Thaler CJ, Noss U. Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2,555 fresh embryo transfers. Fertil Steril. 2012 Aug;98(2):347-54. doi: 10.1016/j.fertnstert.2012.04.041. Epub 2012 May 24.

Reference Type DERIVED
PMID: 22633265 (View on PubMed)

Other Identifiers

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BBN

Identifier Type: OTHER

Identifier Source: secondary_id

Prog2006-2011

Identifier Type: -

Identifier Source: org_study_id