Randomized, Open-label, Parallel Study to Evaluate the Pharmacokinetic Characteristics of Pregabalin According to Different Controlled Released Formulations in Healthy Male Subjects

NCT ID: NCT01420913

Last Updated: 2011-08-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-08-31

Study Completion Date

2011-08-31

Brief Summary

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The purpose of this trial is to compare the pharmacokinetic characteristics of YHD1119 A, YHD1119 B, YHD1119 C and Lyrica capsule.

YHD1119 A, B, C are controlled released formulations which are made by YUHAN Corporation.

Primary endpoints are C max,ss and AUC tau. Secondary endpoints are AUC last, AUC infinity, T max,ss, t 1/2

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Lyrica capsule(Pregabalin 150mg)

Group Type ACTIVE_COMPARATOR

Pregabalin

Intervention Type DRUG

Pregabalin 300mg a day

YHD1119 A(Pregabalin SR 300mg)

Group Type EXPERIMENTAL

Pregabalin

Intervention Type DRUG

Pregabalin 300mg a day

YHD1119 B(Pregabalin SR 300mg)

Group Type EXPERIMENTAL

Pregabalin

Intervention Type DRUG

Pregabalin 300mg a day

YHD1119 C(Pregabalin SR 300mg)

Group Type EXPERIMENTAL

Pregabalin

Intervention Type DRUG

Pregabalin 300mg a day

Interventions

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Pregabalin

Pregabalin 300mg a day

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 20\~45 years old, healthy adult male subject
* \>55 Kg(Body weight) and \< ideal body weight ± 20%

Exclusion Criteria

* AST or ALT \> 1.25 \* Upper normal range (Lab)
* Total bilirubin \> 1.5 \* Upper normal range
* Systolic BP \>140 OR \<100, Diastolic BP \>90 OR \<65
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Yuhan Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Seoul ST.Mary Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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YCD207

Identifier Type: -

Identifier Source: org_study_id

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