Pharmacokinetics and Drug Interaction Study Between Rosuvastatin and CS-866 in Healthy Male Volunteers

NCT ID: NCT01415466

Last Updated: 2012-04-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-08-31

Study Completion Date

2011-10-31

Brief Summary

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The purpose of this study is to evaluate the pharmacokinetics profile and drug-drug interaction between rosuvastatin and CS-866 in healthy male volunteers.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

NONE

Study Groups

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R

multiple dose of Rosuvastatin 20mg

Group Type EXPERIMENTAL

Cresto

Intervention Type DRUG

tablet, 20mg

O

multiple dose of CS-866 40mg

Group Type EXPERIMENTAL

Olmetec

Intervention Type DRUG

tablet, 40mg

R+O

multiple dose of the combination of Rosuvastatin 20mg and CS-866 40mg

Group Type EXPERIMENTAL

Cresto, Olmetec

Intervention Type DRUG

tablet, 20mg and 40mg

Interventions

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Cresto

tablet, 20mg

Intervention Type DRUG

Olmetec

tablet, 40mg

Intervention Type DRUG

Cresto, Olmetec

tablet, 20mg and 40mg

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Healthy adult male volunteers aged 20 to 50 years
2. A subject who provided written informed consent to participate in this study and cooperative with regard to compliance with study related constraints

Exclusion Criteria

1. A subject who had any allergic history to any drug.
2. A subject with sign or symptoms or previously diagnosed disease of liver, kidney, neurology, respiratory, endocrinology, hematology, cardiovascular, genitourinary, psychology, ophthalmic, dermatology and gastrointestinal function or other significant diseases
3. History or suspicion of current drug abuse
4. A subject who had received treatment with below listed drug within specified period prior to the first dose of study medication

* Within 1 month: drug known CYP inducer or inhibitor
* Within 2 weeks: Prescribed or herbal medicine
* Within 1 weeks: OTC medicine
* Within 2 days: Consumption of caffeine
5. A subject who had participated in any other clinical study within the last 2 weeks
6. A subject from whom over 400mL of blood was sampled(whole blood donation) within last 2 weeks or plasma/platelet donation within 1 month.
Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Yonsei University

OTHER

Sponsor Role collaborator

Daewoong Pharmaceutical Co. LTD.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kyungsoo Park, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

YONSEI UNIVERSITY HEALTH SYSTEM (YUHS)

Locations

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Yonsei University Health System (Yuhs)

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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DW_DWJ1276001

Identifier Type: -

Identifier Source: org_study_id

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