Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
650 participants
OBSERVATIONAL
2005-01-31
2020-06-30
Brief Summary
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Detailed Description
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Phenotyping of patients presenting with ovarian dysfunction is of crucial importance when genotyping will be performed. The goal of this genotyping will be the identification of genetic factors associated with the (premature) depletion of the stock of ovarian follicles. It will be performed for isolated WHO III patients in an association (case-control) study for known candidate genes. In familial WHO III cases, genome wide linkage analysis will be performed.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Incipient ovarian failure; defined as normo-ovulatory cycles, raised basal FSH \> 12 IU/L
* Poor response patients; defined as less than 4 oocytes retrieved or cancellation in case of absent follicle growth after ovarian hyperstimulation with 300 IU gonadotropins or cancellation in case of absent follicle growth
* Women with early menopause (between 40-45 years)
* Hypergonadotropic primary amenorrhea
Exclusion Criteria
12 Years
FEMALE
No
Sponsors
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Erasmus Medical Center
OTHER
Medical Center Alkmaar
OTHER
University Medical Center Groningen
OTHER
Leiden University Medical Center
OTHER
Medisch Spectrum Twente
OTHER
Isala
OTHER
Department of Clinical Pharmacy, University Medical Centre St Radboud, The Netherlands.
OTHER
Amphia Hospital
OTHER
Deventer Ziekenhuis
OTHER
Catharina Ziekenhuis Eindhoven
OTHER
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
OTHER
Academisch Ziekenhuis Maastricht
OTHER
Amsterdam UMC, location VUmc
OTHER
UMC Utrecht
OTHER
Responsible Party
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Bart CJM Fauser
professor
Principal Investigators
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Bart CJ Fauser, MD PhD
Role: STUDY_DIRECTOR
UMC Utrecht
Locations
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UMC Utrecht
Utrecht, , Netherlands
Countries
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Central Contacts
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Facility Contacts
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F Janse, MD
Role: primary
References
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Knauff EA, Franke L, van Es MA, van den Berg LH, van der Schouw YT, Laven JS, Lambalk CB, Hoek A, Goverde AJ, Christin-Maitre S, Hsueh AJ, Wijmenga C, Fauser BC; Dutch POF Consortium. Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. Hum Reprod. 2009 Sep;24(9):2372-8. doi: 10.1093/humrep/dep197. Epub 2009 Jun 9.
Knauff EA, Westerveld HE, Goverde AJ, Eijkemans MJ, Valkenburg O, van Santbrink EJ, Fauser BC, van der Schouw YT. Lipid profile of women with premature ovarian failure. Menopause. 2008 Sep-Oct;15(5):919-23. doi: 10.1097/gme.0b013e31816b4509.
Knauff EA, Eijkemans MJ, Lambalk CB, ten Kate-Booij MJ, Hoek A, Beerendonk CC, Laven JS, Goverde AJ, Broekmans FJ, Themmen AP, de Jong FH, Fauser BC; Dutch Premature Ovarian Failure Consortium. Anti-Mullerian hormone, inhibin B, and antral follicle count in young women with ovarian failure. J Clin Endocrinol Metab. 2009 Mar;94(3):786-92. doi: 10.1210/jc.2008-1818. Epub 2008 Dec 9.
Janse F, Knauff EA, Niermeijer MF, Eijkemans MJ, Laven JS, Lambalk CB, Fauser BC, Goverde AJ; Dutch Premature Ovarian Failure Consortium. Similar phenotype characteristics comparing familial and sporadic premature ovarian failure. Menopause. 2010 Jul;17(4):758-65. doi: 10.1097/gme.0b013e3181cf8521.
Knauff EA, Blauw HM, Pearson PL, Kok K, Wijmenga C, Veldink JH, van den Berg LH, Bouchard P, Fauser BC, Franke L; Dutch Primary Ovarian Insufficiency Consortium. Copy number variants on the X chromosome in women with primary ovarian insufficiency. Fertil Steril. 2011 Apr;95(5):1584-8.e1. doi: 10.1016/j.fertnstert.2011.01.018. Epub 2011 Feb 12.
Other Identifiers
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METC 05-047
Identifier Type: -
Identifier Source: org_study_id