Reducing the Need for In-Clinic Follow-Up for Medical Abortion in Moldova and Uzbekistan

NCT ID: NCT01410266

Last Updated: 2012-12-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

2400 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-09-30

Study Completion Date

2012-10-31

Brief Summary

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The purpose of this study is to determine whether an alternative method of follow-up after medical abortion is acceptable and feasible for use in Moldova and Uzbekistan.

Detailed Description

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Medical abortion using mifepristone and misoprostol is a highly effective procedure, but access to it may be impeded by the fact that not all women can afford or want to return for a follow-up visit. This often results in a high loss to follow-up rate. Additionally, with medical abortions of those women who do return for follow-up, higher costs are borne by both the woman and the healthcare system.

This study compares two methods of follow-up after medical abortion: standard of care versus alternative follow-up. The former involves a routine clinic visit two weeks after misoprostol administration. The latter consists of a low-sensitivity pregnancy test and a self-administered questionnaire. Based on the results of the test and questionnaire, women may be flagged as needing in-clinic follow-up or discharged from the study if their abortion is complete.

Conditions

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Medical Abortion, Fetus

Keywords

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medical abortion first trimester follow-up pregnancy test

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Standard of care

Standard of care includes a routine clinic visit two weeks after misoprostol administration. At the clinic visit, the woman undergoes a bimanual examination. In the event the woman fails to return for the follow-up visit, clinic procedure is followed for contacting her to determine abortion status and the need for further intervention, if any.

Group Type NO_INTERVENTION

No interventions assigned to this group

Alternative follow-up

At a clinic visit, before mifepristone administration, the woman completes a semi-quantitative pregnancy test. After mifepristone administration, she is provided with another pregnancy test and a checklist to be self-administered two weeks after she takes misoprostol. On an assigned date, the woman is contacted by phone by the clinic staff and asked to report on the results of both tests. The provider then confirms whether, based on the woman's responses, she should return for a follow-up visit.

Group Type ACTIVE_COMPARATOR

Alternative follow-up

Intervention Type OTHER

Alternative follow-up consists of a self-administered semi-quantitative pregnancy test designed to measure urine beta-hCG levels, and a self-administered questionnaire consisting of 7 questions. Results of both are reviewed by the provider to determine if in-clinic follow-up is needed.

Interventions

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Alternative follow-up

Alternative follow-up consists of a self-administered semi-quantitative pregnancy test designed to measure urine beta-hCG levels, and a self-administered questionnaire consisting of 7 questions. Results of both are reviewed by the provider to determine if in-clinic follow-up is needed.

Intervention Type OTHER

Other Intervention Names

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semi-quantitative pregnancy test self-administered questionnaire

Eligibility Criteria

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Inclusion Criteria

* Reproductive-age woman seeking a medical abortion
* Woman in good general health
* Woman with an intrauterine pregnancy less than or equal to 63 days gestation on the day of mifepristone administration
* Woman able and willing to sign consent forms
* Woman eligible for medical abortion according to clinician's assessment
* Woman agreeing to be followed up with, by phone or at a clinic visit

Exclusion Criteria

* Woman with a pregnancy greater than 63 days gestation on the day of mifepristone administration
Minimum Eligible Age

16 Years

Maximum Eligible Age

55 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Gynuity Health Projects

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hillary J. Bracken, PhD, MHS, MA

Role: PRINCIPAL_INVESTIGATOR

Gynuity Health Projects

Beverly Winikoff, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

Gynuity Health Projects

Locations

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The Perinatalogy Center

Bălţi, , Moldova

Site Status

Municipal Clinical Hospital

Chisinau, , Moldova

Site Status

The National Center of Reproductive Health and Medical Genetics

Chisinau, , Moldova

Site Status

The Center of Women Health "Ana"

Drochia, , Moldova

Site Status

Clinic #2 of Tashkent Medical Academy

Tashkent, , Uzbekistan

Site Status

Municipal Maternity House #10

Tashkent, , Uzbekistan

Site Status

Women's Wellness Center

Tashkent, , Uzbekistan

Site Status

Countries

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Moldova Uzbekistan

References

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Platais I, Tsereteli T, Comendant R, Kurbanbekova D, Winikoff B. Acceptability and feasibility of phone follow-up with a semiquantitative urine pregnancy test after medical abortion in Moldova and Uzbekistan. Contraception. 2015 Feb;91(2):178-83. doi: 10.1016/j.contraception.2014.11.004. Epub 2014 Nov 15.

Reference Type DERIVED
PMID: 25497383 (View on PubMed)

Other Identifiers

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6.5

Identifier Type: -

Identifier Source: org_study_id