Trial Outcomes & Findings for Bystander Fatigue and CPR Quality Using Continuous Compressions Versus 30:2 Compressions to Ventilation (NCT NCT01397656)

NCT ID: NCT01397656

Last Updated: 2018-11-15

Results Overview

Count of compressions at a depth over 2 inches

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 63 participants
• Primary outcome timeframe: 5 minutes
• Results posted on: 2018-11-15

Participant Flow

Participant milestones

Measure	CPR 30:2 Then CPR With Continuous Compressions 30 chest compressions to 2 ventilations, then continuous chest compressions Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation	CPR With Continuous Compressions Then CPR 30:2 Continuous Chest Compressions without ventilation then CPR using 30:2 ratio Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation
Overall Study STARTED	33	30
Overall Study COMPLETED	33	30
Overall Study NOT COMPLETED	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Bystander Fatigue and CPR Quality Using Continuous Compressions Versus 30:2 Compressions to Ventilation

Baseline characteristics by cohort

Measure	CPR 30:2 Then CPR With Continuous Compressions n=33 Participants 30 chest compressions to 2 ventilations Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation	CPR With Continuous Compressions Then CPR 30:2 n=30 Participants Continuous Chest Compressions without ventilation Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation	Total n=63 Participants Total of all reporting groups
Age, Continuous	71.6 years STANDARD_DEVIATION 6.5 • n=5 Participants	69.9 years STANDARD_DEVIATION 6.3 • n=7 Participants	70.8 years STANDARD_DEVIATION 6.4 • n=5 Participants
Sex: Female, Male Female	23 Participants n=5 Participants	19 Participants n=7 Participants	42 Participants n=5 Participants
Sex: Female, Male Male	10 Participants n=5 Participants	11 Participants n=7 Participants	21 Participants n=5 Participants
Region of Enrollment Canada	33 participants n=5 Participants	30 participants n=7 Participants	63 participants n=5 Participants
CPR Training	18 Participants n=5 Participants	20 Participants n=7 Participants	38 Participants n=5 Participants
CPR Experience	3 Participants n=5 Participants	3 Participants n=7 Participants	6 Participants n=5 Participants

PRIMARY outcome

Timeframe: 5 minutes

Count of compressions at a depth over 2 inches

Outcome measures

Measure	CPR 30:2 n=62 Participants 30 chest compressions to 2 ventilations	CPR With Continuous Compressions n=63 Participants Continuous Chest Compressions without ventilation Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation
CPR Quality	324.9 Compressions Standard Deviation 120	381.5 Compressions Standard Deviation 68.5

SECONDARY outcome

Timeframe: Assessed immediately before and after 5 minutes of CPR

Outcome measures

Measure	CPR 30:2 n=62 Participants 30 chest compressions to 2 ventilations	CPR With Continuous Compressions n=63 Participants Continuous Chest Compressions without ventilation Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation
Heart Rate	82.8 beats per minute Standard Deviation 16.1	82.4 beats per minute Standard Deviation 15.1

SECONDARY outcome

Timeframe: Assessed immediately before and after 5 minutes of CPR

Mean arterial pressure (mmHg)

Outcome measures

Measure	CPR 30:2 n=62 Participants 30 chest compressions to 2 ventilations	CPR With Continuous Compressions n=63 Participants Continuous Chest Compressions without ventilation Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation
Blood Pressure	109.8 mmHg Standard Deviation 10.7	110.3 mmHg Standard Deviation 11.5

SECONDARY outcome

Timeframe: Assessed immediately before and after 5 minutes of CPR

The Borg Rating of Perceived Exertion scale ranges from 6-20, where a score of 6 is associated with the least fatigue

Outcome measures

Measure	CPR 30:2 n=62 Participants 30 chest compressions to 2 ventilations	CPR With Continuous Compressions n=63 Participants Continuous Chest Compressions without ventilation Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation
Borg Rating of Perceived Exertion Scale	11.0 units on a scale Standard Deviation 2.6	11.6 units on a scale Standard Deviation 3.0

Adverse Events

CPR 30:2 Then CPR With Continuous Compressions

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

CPR With Continuous Compressions Then CPR 30:2

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Christian Vaillancourt

Ottawa Hospital Research Institute

Phone: 613-798-5555

Email: cvaillancourt@ohri.ca

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place