Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft
NCT ID: NCT01394419
Last Updated: 2013-03-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
115 participants
INTERVENTIONAL
2010-09-30
2012-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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NAC group
N-acetylcysteine
N-acetylcysteine
N-acetylcysteine 150 mg/kg bolus over 15 min after induction of anesthesia, followed by an infusion of 150 mg/kg/day for 24 hrs
Placebo group
Saline
Saline
Equal volume of normal saline
Interventions
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N-acetylcysteine
N-acetylcysteine 150 mg/kg bolus over 15 min after induction of anesthesia, followed by an infusion of 150 mg/kg/day for 24 hrs
Saline
Equal volume of normal saline
Eligibility Criteria
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Inclusion Criteria
* preoperative serum creatinine \> 1.4 mg/dl
* Age \> 70 years
* Diabetes mellitus
* left ventricular ejection fraction \< 35 % or congestive heart failure (NYHA III or IV)
* emergency surgery or re-operation
Exclusion Criteria
20 Years
ALL
No
Sponsors
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Yonsei University
OTHER
Responsible Party
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Locations
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Severance Hospital
Seoul, , South Korea
Countries
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References
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Song JW, Shim JK, Soh S, Jang J, Kwak YL. Double-blinded, randomized controlled trial of N-acetylcysteine for prevention of acute kidney injury in high risk patients undergoing off-pump coronary artery bypass. Nephrology (Carlton). 2015 Feb;20(2):96-102. doi: 10.1111/nep.12361.
Other Identifiers
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4-2010-0135
Identifier Type: -
Identifier Source: org_study_id
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