MgSO4 Combined With Rocuronium Priming

NCT ID: NCT01389791

Last Updated: 2012-01-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2012-01-31

Brief Summary

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Priming with either rocuronium or MgSO4 is known to accelerate the effect of rocuronium on muscle relaxation. The purpose of this study is to define the effect of MgSO4 on the rocuronium-priming.

Detailed Description

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Acceleration of muscle relaxation is beneficial in rapid-sequence intubation. If MgSO4 combined with priming is efficient in accelerating muscle relaxation, it would be an interesting alternative to rapid-sequence intubation.

Conditions

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Muscle Relaxation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Roc

Patients in this group receive neither MgSO4 nor priming dose of rocuronium.

Group Type NO_INTERVENTION

No interventions assigned to this group

priming

patients in this group receive 0.06mg/kg of rocuronium before 0.54mg/kg of rocuronium.

Group Type ACTIVE_COMPARATOR

priming

Intervention Type DRUG

Patients in this group receive 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.

Mg&priming

Patients in this group receive MgSO4 50mg/kg and 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.

Group Type EXPERIMENTAL

magnesium sulfate and priming

Intervention Type DRUG

Patients in this group receive MgSO4 50mg/kg and 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.

MgSO4

Patients in this group receive intravenous MgSO4 before administration of rocuronium.

Group Type ACTIVE_COMPARATOR

magnesium sulfate

Intervention Type DRUG

Patients in this group receive intravenous MgSO4 50mg/kg before administration of rocuronium (induction dose).

Interventions

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magnesium sulfate

Patients in this group receive intravenous MgSO4 50mg/kg before administration of rocuronium (induction dose).

Intervention Type DRUG

priming

Patients in this group receive 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.

Intervention Type DRUG

magnesium sulfate and priming

Patients in this group receive MgSO4 50mg/kg and 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.

Intervention Type DRUG

Other Intervention Names

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MgSO4 rocuronium-priming MgSO4 & priming

Eligibility Criteria

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Inclusion Criteria

* patients of ASA Ⅰ-Ⅱ
* aged 18\~65
* scheduled to undergo elective surgery under general anesthesia

Exclusion Criteria

* risk of pulmonary aspiration
* anticipated airway difficulty
* reactive airway disease
* allergic to study drugs
* neuromuscular / cardiovascular/ renal/ hepatic disease
* atrioventricular conduction disturbance
* BMI \< 18.5 or \> 24.9
* chronic treatment with calcium channel blocker
* medications which affect muscle relaxation
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Bundang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Kim Mihyun

full instructor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sanghwan Do, M.D., PH.D.

Role: STUDY_CHAIR

Seoul National University Bundang Hospital

Locations

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Seoul national university Bundang hospital

Seongnam, Kyoung-ki-do, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Mihyun Kim, MD

Role: CONTACT

82-31-787-2034

Other Identifiers

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Mg priming

Identifier Type: -

Identifier Source: org_study_id

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