T-cell-immunity During Standard Radiotherapy in Localised Prostate Cancer
NCT ID: NCT01376674
Last Updated: 2013-08-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
22 participants
OBSERVATIONAL
2011-03-31
Brief Summary
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In order to identify a possible time frame for combination therapies, white blood cells are isolated of samples taken at different time points before during and after standard radiotherapy in patients with localised prostate cancer. The overall activity of the T-cell-system as well as tumor-specific T-cell-response are evaluated.
Detailed Description
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Conditions
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Keywords
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Study Design
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CASE_ONLY
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* definitive radiotherapy
* informed consent
Exclusion Criteria
18 Years
90 Years
MALE
No
Sponsors
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University Hospital Tuebingen
OTHER
Responsible Party
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Franziska Eckert
M.D.
Principal Investigators
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Cihan Gani, M.D.
Role: PRINCIPAL_INVESTIGATOR
University Hospital Tuebingen
Franziska Eckert, MD
Role: STUDY_DIRECTOR
University Hospital Tuebingen
Locations
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Department of Radiation Oncology
Tübingen, , Germany
Countries
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References
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Widenmeyer M, Shebzukhov Y, Haen SP, Schmidt D, Clasen S, Boss A, Kuprash DV, Nedospasov SA, Stenzl A, Aebert H, Wernet D, Stevanovic S, Pereira PL, Rammensee HG, Gouttefangeas C. Analysis of tumor antigen-specific T cells and antibodies in cancer patients treated with radiofrequency ablation. Int J Cancer. 2011 Jun 1;128(11):2653-62. doi: 10.1002/ijc.25601. Epub 2010 Oct 8.
Hoffmann E, Paulsen F, Schaedle P, Zips D, Gani C, Rammensee HG, Gouttefangeas C, Eckert F. Radiotherapy planning parameters correlate with changes in the peripheral immune status of patients undergoing curative radiotherapy for localized prostate cancer. Cancer Immunol Immunother. 2022 Mar;71(3):541-552. doi: 10.1007/s00262-021-03002-6. Epub 2021 Jul 16.
Eckert F, Schaedle P, Zips D, Schmid-Horch B, Rammensee HG, Gani C, Gouttefangeas C. Impact of curative radiotherapy on the immune status of patients with localized prostate cancer. Oncoimmunology. 2018 Aug 27;7(11):e1496881. doi: 10.1080/2162402X.2018.1496881. eCollection 2018.
Other Identifiers
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UKT_RO_01
Identifier Type: -
Identifier Source: org_study_id