Safety and Pharmacokinetic Study of EO9(Intravesical Instillation)

NCT ID: NCT01373398

Last Updated: 2012-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

11 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Brief Summary

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The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of intravesical instillation of EO9 in patients with non-muscle invasive bladder cancer (NMIBC).

Detailed Description

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Conditions

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Bladder Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Interventions

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EO9(Apaziquone)

immediate instillation after TURBT + 6 weekly instillation 4mg/mL Apaziquone

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients who are clinically diagnosed as having stage Ta, T1, histological grade G1, G2 urothelial carcinoma of the bladder
* Patients who are confirmed to be urinary cytology negative (class I, class II) within 4 weeks prior to the present TURBT.
* P.S : 0-2 according to the ECOG.

Exclusion Criteria

* Patients with a primary and solitary tumor.
* CIS lesions in the bladder or a history thereof.
* Grade 3 disease or a history thereof.
* Patients experiencing recurrence within 3 months following TURBT for prior NMIBC.
* Patients having stage T1 and high-grade disease.
* Invasive cancer of T2 or greater, with definite lymph node or other organ metastasis, or a history thereof.
* Patients who received intravesical chemotherapy/immunotherapy treatment within 6 months prior to the present TURBT.
* Patients who underwent systemic chemotherapy or radiotherapy whose field of exposure included the bladder.
* Patients with suspected bladder perforation at the time of the present TURBT.
* A complication of a malignant tumor of the upper urinary tract or urethra, or a history thereof.
* Malignancy within 5 years other than NMIBC (except thyroid cancer)
* A serious viral or bacterial infection within the last 4 weeks.
Minimum Eligible Age

20 Years

Maximum Eligible Age

74 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Handok Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Site 01

Seoul, , South Korea

Site Status

Site 02

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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HD901_01

Identifier Type: -

Identifier Source: org_study_id

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