A 6-Month Open-Label Extension Study to the B2061014 Study to Evaluate the Safety, Tolerability and Efficacy of DVS SR in the Treatment of Children and Adolescents With MDD

NCT ID: NCT01371721

Last Updated: 2017-02-08

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

269 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-02-29

Study Completion Date

2015-10-31

Brief Summary

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This is a 6-month, open-label, flexible-dose study evaluating desvenlafaxine succinate sustained release (DVS SR) in the treatment of child and adolescent outpatients with major depressive disorder (MDD).

Detailed Description

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Conditions

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Major Depressive Disorder

Study Design

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Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Desvenlafaxine Succinate Sustained-Release

Group Type EXPERIMENTAL

DVS SR

Intervention Type DRUG

Subjects will receive a flexible-dose of 20, 25, 35 or 50 mg/day as prescribed by the investigator.

Interventions

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DVS SR

Subjects will receive a flexible-dose of 20, 25, 35 or 50 mg/day as prescribed by the investigator.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Completed study B2061014 and who in the investigator's opinion would benefit from long term treatment with DVS SR
* Willingness and ability to comply with scheduled visits, treatment plan and procedures

Exclusion Criteria

* Subject requires precaution against suicide
* Subject not in a generally healthy condition
Minimum Eligible Age

7 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Harmonex Neuroscience Research, Inc.

Dothan, Alabama, United States

Site Status

Dedicated Clinical Research

Goodyear, Arizona, United States

Site Status

University of Arizona Clinical and Translational Science Center (CATS)

Tucson, Arizona, United States

Site Status

University of Arizona College of Medicine Dept of Psychiatry

Tucson, Arizona, United States

Site Status

Arkansas Psychiatric Clinic Clinical Research Trials, P.A.

Little Rock, Arkansas, United States

Site Status

ATP Clinical Research, Incorporated

Costa Mesa, California, United States

Site Status

Behavioral Research Specialists, LLC

Glendale, California, United States

Site Status

Synergy Clinical Research Center

National City, California, United States

Site Status

Neuropsychiatric Research Center of Orange County

Orange, California, United States

Site Status

Pacific Clinical Research Medical Group

Orange, California, United States

Site Status

Elite Clinical Trials, Incorporated

Wildomar, California, United States

Site Status

Children's Hospital Colorado

Aurora, Colorado, United States

Site Status

Amedica Research Institute, Incorporated

Hialeah, Florida, United States

Site Status

Clinical Neuroscience Solutions, Inc.

Orlando, Florida, United States

Site Status

Kolin Research Group

Winter Park, Florida, United States

Site Status

Atlanta Center for Medical Research

Atlanta, Georgia, United States

Site Status

Institute for Behavioral Medicine, LLC

Smyrna, Georgia, United States

Site Status

Psychiatric Associates

Overland Park, Kansas, United States

Site Status

Lake Charles Clinical Trials,

Lake Charles, Louisiana, United States

Site Status

Precise Research Centers

Flowood, Mississippi, United States

Site Status

St. Charles Psychiatric Associates - Midwest Research Group

Saint Charles, Missouri, United States

Site Status

Center for Psychiatry and Behavioral Medicine, Incorporated

Las Vegas, Nevada, United States

Site Status

North Star Medical Research, LLC

Middleburg Heights, Ohio, United States

Site Status

IPS Research Company

Oklahoma City, Oklahoma, United States

Site Status

Cutting Edge Research Group

Oklahoma City, Oklahoma, United States

Site Status

Paradigm Research Professionals, LLC

Oklahoma City, Oklahoma, United States

Site Status

Summit Research Network (Oregon), Incorporated

Portland, Oregon, United States

Site Status

Clinical Neuroscience Solutions, Inc.

Memphis, Tennessee, United States

Site Status

Focus & Balance, LLC

San Antonio, Texas, United States

Site Status

Grayline Clinical Drug Trials

Witchita Falls, Texas, United States

Site Status

Northwest Clinical Research Center

Bellevue, Washington, United States

Site Status

Summit Research Network (Seattle) LLC

Seattle, Washington, United States

Site Status

Rogers Center for Research and Training, Incorporated

Milwaukee, Wisconsin, United States

Site Status

Hospital Aranda de la Parra, S.A. de C.V.

León, Guanajuato, Mexico

Site Status

CIT-Neuropsique, S.C.

Monterrey, Nuevo León, Mexico

Site Status

Countries

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United States Mexico

References

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Atkinson S, Thurman L, Ramaker S, Buckley G, Jones SR, England R, Wajsbrot D. Safety, Tolerability, and Efficacy of Desvenlafaxine in Children and Adolescents with Major Depressive Disorder: Results from Two Open-Label Extension Trials. CNS Spectr. 2019 Oct;24(5):496-506. doi: 10.1017/S1092852918001128.

Reference Type DERIVED
PMID: 30419989 (View on PubMed)

Related Links

Other Identifiers

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3151A6-3357

Identifier Type: OTHER

Identifier Source: secondary_id

2008-002064-34

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

B2061031

Identifier Type: -

Identifier Source: org_study_id

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