Attention Bias Modification Treatment (ABMT) for Patients With Post Traumatic Stress Disorder (PTSD)

NCT ID: NCT01368302

Last Updated: 2014-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-31

Study Completion Date

2013-03-31

Brief Summary

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Patients with Post Traumatic Stress Disorder (PTSD) will be randomly assigned to either Attention Bias Modification Treatment (ABMT) designed to normalize threat-related attention biases or a placebo control condition not designed to change attention patterns. Outcome measures will be Post Traumatic Stress Disorder (PTSD), depression, and anxiety symptoms as measured by gold standard questionnaires and symptom counts derived from structured clinical interviews.

We expect to see significant Post Traumatic Stress Disorder symptom reduction in the Attention Bias Modification Treatment (ABMT) group relative to the placebo control group in which no symptomatic relief is expected.

Detailed Description

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Conditions

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Attention Bias Modification Treatment (ABMT)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Attention Bias Modification (ABM)

Attention training via repeated trials of a dot-probe task intended to normalize threat-related attention biases.

Group Type EXPERIMENTAL

Attention Bias Modification Treatment (ABMT)

Intervention Type BEHAVIORAL

Attention training using a computerized spatial attention task (dot-probe) modified to alter threat-related attention patterns.

Placebo

Attention training via repeated trials of a dot-probe task not intended to change threat-related attention patterns.

Group Type PLACEBO_COMPARATOR

Attention Bias Modification Treatment (ABMT)

Intervention Type BEHAVIORAL

Attention training using a computerized spatial attention task (dot-probe) modified to alter threat-related attention patterns.

Interventions

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Attention Bias Modification Treatment (ABMT)

Attention training using a computerized spatial attention task (dot-probe) modified to alter threat-related attention patterns.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Combat-related PTSD diagnosis

Exclusion Criteria

* Other treatment
Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Tel Aviv University

OTHER

Sponsor Role lead

Responsible Party

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Yair Bar-Haim

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Tel Aviv University

Tel Aviv, , Israel

Site Status

Countries

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Israel

References

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Hakamata Y, Lissek S, Bar-Haim Y, Britton JC, Fox NA, Leibenluft E, Ernst M, Pine DS. Attention bias modification treatment: a meta-analysis toward the establishment of novel treatment for anxiety. Biol Psychiatry. 2010 Dec 1;68(11):982-90. doi: 10.1016/j.biopsych.2010.07.021.

Reference Type BACKGROUND
PMID: 20887977 (View on PubMed)

Badura-Brack AS, Naim R, Ryan TJ, Levy O, Abend R, Khanna MM, McDermott TJ, Pine DS, Bar-Haim Y. Effect of Attention Training on Attention Bias Variability and PTSD Symptoms: Randomized Controlled Trials in Israeli and U.S. Combat Veterans. Am J Psychiatry. 2015 Dec;172(12):1233-41. doi: 10.1176/appi.ajp.2015.14121578. Epub 2015 Jul 24.

Reference Type DERIVED
PMID: 26206075 (View on PubMed)

Other Identifiers

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949-2010

Identifier Type: -

Identifier Source: org_study_id