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Gut Hormones After Meal Ingestion in Males Versus Females

NCT ID: NCT01366781

Last Updated: 2014-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2014-06-30

Brief Summary

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The study hypothesis is that the release of gut hormones is increased proportionally to caloric load in each meal. Three different meals with different meal size will therefore be served and gut hormones determined.

Detailed Description

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In healthy males and females, meals with 511, 743 and 1034 kcal will be given orally. Samples will be taken during the following 300 min and gut hormones (glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1) will be determined along with insulin and glucagon levels.

Conditions

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Normal Non-fluency

Keywords

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Gut hormones Insulin secretion

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

FACTORIAL

Blinding Strategy

NONE

Study Groups

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Healthy males

Meal ingestion in healthy males

Group Type EXPERIMENTAL

Meal ingestion

Intervention Type OTHER

Meal 511 kcal, meal 743 kcal or meal 1034 kcal

Healthy females

Meal ingestion in healthy females

Group Type EXPERIMENTAL

Meal ingestion

Intervention Type OTHER

Meal 511 kcal, meal 743 kcal or meal 1034 kcal

Interventions

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Meal ingestion

Meal 511 kcal, meal 743 kcal or meal 1034 kcal

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy status

Exclusion Criteria

* Diabetes
* Liver disease
* kidney disease
* thyroid disease
Minimum Eligible Age

20 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Lund University

OTHER

Sponsor Role lead

Responsible Party

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Bo Ahren

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bo Ahrén, PhD

Role: PRINCIPAL_INVESTIGATOR

Lund University

Locations

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Department of Clinical Sciences Lund, Lund University

Lund, , Sweden

Site Status

Countries

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Sweden

References

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Alsalim W, Omar B, Pacini G, Bizzotto R, Mari A, Ahren B. Incretin and islet hormone responses to meals of increasing size in healthy subjects. J Clin Endocrinol Metab. 2015 Feb;100(2):561-8. doi: 10.1210/jc.2014-2865. Epub 2014 Nov 6.

Reference Type DERIVED
PMID: 25375983 (View on PubMed)

Other Identifiers

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004

Identifier Type: -

Identifier Source: org_study_id