French National Cohort of Children With Port Wine Stain
NCT ID: NCT01364857
Last Updated: 2025-12-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
150 participants
INTERVENTIONAL
2010-11-30
2019-11-30
Brief Summary
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Little is known about epidemiology of port wine stains: their evolution during the growth of the child, the frequency of complications, genetic data, and prognostic factors.
This prospective french national cohort will help for : description of the evolution of port wine stain and possible complications; prognostic factors for complications ; association with mutations of RASA1 gene; quality of life of these children. It will also help for global appreciation of the management of this disease in France.
Detailed Description
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Methods : each children with a port wine stain on a lower limb will be followed up for 5 years.
Collected data : demographic data, clinical features, alterations of RASA1 gene, vascular evaluation by ultrasonographic and orthopedic evaluation by X rays, quality of life with a questionnaire.
Inclusion period = 3 years Follow up period = 5 years Population = 150 children
Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
PREVENTION
NONE
Study Groups
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PWS cohort
search for polymorphisms of RASA1 gene
search for polymorphisms of RASA1 gene
Blood sample ( 5 mL) at tne inclusion of the child DNA extraction and genetic analysis of the 24 exons of RASA1 gene after specific consent
Interventions
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search for polymorphisms of RASA1 gene
Blood sample ( 5 mL) at tne inclusion of the child DNA extraction and genetic analysis of the 24 exons of RASA1 gene after specific consent
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2 Years
12 Years
ALL
No
Sponsors
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University Hospital, Tours
OTHER
Responsible Party
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Principal Investigators
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Violaine MIZZI
Role: STUDY_CHAIR
University Hospital, Tours
Locations
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Service de dermatologie
Amiens, , France
Service de dermatologie
Angers, , France
Service de dermatologie
Bordeaux, , France
Service de dermatologie
Caen, , France
Service de dermatologie
Dijon, , France
Service de Dermatologie, Bâtiment tardieu
Le Mans, , France
Service de Dermatologie, Hôpital St Eloi
Montpellier, , France
Service de dermatologie
Nantes, , France
Service de dermatologie
Nice, , France
Service de dermatologie
Paris, , France
Service de dermatlogie
Quimper, , France
Service de dermatologie
Reims, , France
Service de Dermatologie, Hôpital Pontchaillou, CHU de Rennes
Rennes, , France
Service de dermatologie
Rouen, , France
Service de dermatologie
Saint-Etienne, , France
Service de dermatologie
Toulouse, , France
Service de dermatologie
Tours, , France
Countries
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References
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Maruani A, Durieux-Verde M, Mazereeuw-Hautier J, Boccara O, Martin L, Chiaverini C, Eschard C, Beneton N, Vabres P, Balguerie X, Plantin P, Bessis D, Barbarot S, Dadban A, Droitcourt C, Berthelot A, Lorette G, Leducq S, Samimi M, Andres C, Caille A, Vourc'h P; Groupe de Recherche de la Societe Francaise de Dermatologie. Search for RASA1 Variants in Capillary Malformations of the Legs in 113 Children: Results from the French National Paediatric Cohort CONAPE. Acta Derm Venereol. 2018 Feb 7;98(2):251-255. doi: 10.2340/00015555-2835.
Other Identifiers
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PHRN09 - GL / CONAPE
Identifier Type: -
Identifier Source: org_study_id