A Study to Evaluate the Efficacy and Safety of SPN-810 as Adjunctive Therapy in Children With Impulsive Aggression Comorbid With Attention-Deficit/Hyperactivity Disorder (ADHD)

NCT ID: NCT01364662

Last Updated: 2021-02-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

121 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2012-10-31

Brief Summary

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This will be a randomized, double-blind, placebo-controlled, dose-ranging, efficacy and safety study in children with impulsive aggression comorbid with Attention-Deficit/Hyperactivity Disorder (ADHD). The target subjects are healthy male and female children aged 6 to 12 years, inclusive, with a diagnosis of ADHD. A total of 120 subjects will be randomized across approximately 30 US centers to one of four treatment groups.

Detailed Description

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Conditions

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Impulsive Aggression Comorbid With ADHD

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

Group Type EXPERIMENTAL

Placebo

Intervention Type DRUG

administered orally

2

Group Type EXPERIMENTAL

SPN-810

Intervention Type DRUG

administered orally

3

Group Type EXPERIMENTAL

SPN-810

Intervention Type DRUG

administered orally

4

Group Type EXPERIMENTAL

SPN-810

Intervention Type DRUG

administered orally

Interventions

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SPN-810

administered orally

Intervention Type DRUG

Placebo

administered orally

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Healthy pediatric male or female subjects, age 6 to 12 years.
2. Diagnostic and Statistical Manual of Mental Disorders - IV -Text Revision (DSM-IV-TR) diagnosis of ADHD.
3. R-MOAS score \>=24 at screening and R-MOAS score \>=20 for randomization
4. IQ greater than 71.
5. Weight of \>=20kg
6. current treatment with psychostimulant (1 month prior to screening)
Minimum Eligible Age

6 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Supernus Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Dothan, Alabama, United States

Site Status

Los Angeles, California, United States

Site Status

Santa Ana, California, United States

Site Status

Washington D.C., District of Columbia, United States

Site Status

Bradenton, Florida, United States

Site Status

Gainesville, Florida, United States

Site Status

Hialeah, Florida, United States

Site Status

Jacksonville, Florida, United States

Site Status

Maitland, Florida, United States

Site Status

North Miami, Florida, United States

Site Status

Orlando, Florida, United States

Site Status

Tampa, Florida, United States

Site Status

Atlanta, Georgia, United States

Site Status

Libertyville, Illinois, United States

Site Status

Indianapolis, Indiana, United States

Site Status

Terre Haute, Indiana, United States

Site Status

Owensboro, Kentucky, United States

Site Status

Toms River, New Jersey, United States

Site Status

Stony Brook, New York, United States

Site Status

Cleveland, Ohio, United States

Site Status

Columbus, Ohio, United States

Site Status

Philadelphia, Pennsylvania, United States

Site Status

Pittsburgh, Pennsylvania, United States

Site Status

Charleston, South Carolina, United States

Site Status

Memphis, Tennessee, United States

Site Status

Bellevue, Washington, United States

Site Status

Bothell, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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810P202

Identifier Type: -

Identifier Source: org_study_id

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