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Hyperbaric Oxygen Treatment Ameliorates Insulin Resistance

NCT ID: NCT01361971

Last Updated: 2013-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-04-30

Study Completion Date

2013-01-31

Brief Summary

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Obesity is an epidemic in Western society and is the biggest risk factor for insulin resistance and type 2 diabetes. The investigators have preliminary evidence showing that hyperbaric oxygen therapy rapidly increases insulin sensitivity in humans. This requires confirmation in a larger population, and with this study the investigators will also test for mechanisms how this occurs. The investigators suspect that modulation of hypoxia and stress response proteins following changes in tissue oxygenation may contribute to these improvements. This study has the potential to yield new and important insights into the insulin resistance in obesity.

Detailed Description

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Conditions

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Obesity Type 2 Diabetes

Keywords

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Insulin resistance Inflammation Hypoxia

Study Design

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Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Interventions

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Hyperbaric Oxygen Treatment

Participants will undergo 4 treatments of hyperbaric oxygen. Each treatment consists of 90 minutes compression at 2 atmospheres of pressure, with 30 minutes decompression back to 1 atmosphere, during this time, patients will be treated with 100% Oxygen delivered via a hood system.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Obese men with and without type 2 diabetes aged 45-70
* Lean men without type 2 diabetes aged 45-70

Exclusion Criteria

* smokers
* claustrophobic
* sleep apnoea
* blood donor
* exercise more than 2 times per week
* under certain medications eg: bleomycin,corticosteroid
Minimum Eligible Age

45 Years

Maximum Eligible Age

70 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Adelaide

OTHER

Sponsor Role lead

Responsible Party

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A/Prof Leonie Heilbronn

A/Prof

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Leonie K Heilbronn, Phd

Role: PRINCIPAL_INVESTIGATOR

University of Adelaide

Locations

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University of Adelaide

Adelaide, South Australia, Australia

Site Status

Countries

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Australia

Other Identifiers

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RAH100615

Identifier Type: -

Identifier Source: org_study_id