Reaching Exercise Goals: Comparison of Exercise Means in Patients With Knee Osteoarthritis
NCT ID: NCT01359124
Last Updated: 2015-02-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
60 participants
OBSERVATIONAL
2011-05-31
2012-05-31
Brief Summary
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The secondary objective is to compare exercise tolerance for water based treadmill, land based treadmill, and upright cycling in meeting American College of Sports Medicine exercise goals for moderate exercise.
The tertiary objective is to evaluate quality of life improvements for water based treadmill exercise, land based treadmill exercise, and upright cycling.
Detailed Description
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Exercise has been shown to help maintain function in knee osteoarthritis \[5\]. Aerobic walking and quadriceps strengthening exercises (\[18\];\[7\]) and resistance training \[15\] have demonstrated that exercise can potentially improve pain and function in individuals with knee osteoarthritis. Likewise, a Cochrane review on aquatic exercise provided gold level evidence that aquatic exercise probably reduces pain and increases function over 3 months; but, it stated clearly that more research was needed to understand which type of aquatic exercise, how often, and for how long might be beneficial \[2\]. The American College of Sports Medicine (ACSM) recommendations for healthy adults recommend moderate-intensity aerobic exercise (endurance) physical activity for a minimum of 30 minutes, 5 days per week or vigorous-intensity aerobic physical activity for a minimum of 20 minutes, 3 days per week in all healthy adults aged 18 to 65 to promote and maintain health \[9\]. The best method of reaching current ACSM goals in patients with knee osteoarthritis is not known, as impact-related exercise certainly demands healthy joints and many patients with knee osteoarthritis do not tolerate this form of exercise.
In counseling patients with knee osteoarthritis, the question remains: how best to exercise to reach the ACSM goals for exercise. This study will compare water-based and land-based treadmill exercise and upright cycling in meeting ACSM exercise goals for moderate exercise.
Interested subjects will undergo knee radiographs to confirm presence and degree of knee osteoarthritis. Eligible participants will then be randomized into one of the three exercise cohorts. During each session, participants will complete between 10 to 45 minutes of exercise, with a goal of achieving 30 minutes of moderate aerobic exercise. All subjects will only participate in routine activities for the 8 week study period outside of the study protocol (no strength training, cardio training, etc.). Health status measurement questionnaires (WOMAC, KOOS, and SF12) will be completed at the time of randomization and at the conclusion of each week of exercise for a total of 9 times.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Water Treadmill
These subjects will participate in three monitored exercise sessions per week for 8 weeks using a water-based treadmill.
Water-based Treadmill
Exercise regimen: three monitored exercise sessions per week for eight weeks using the water-based treadmill.
Land Treadmill
These subjects will participate in three monitored exercise sessions per week for 8 weeks using a land-based treadmill.
Land-based Treadmill
Exercise regimen: three monitored exercise sessions per week for eight weeks using the land-based treadmill.
Exercise Cycle
These subjects will participate in three monitored exercise sessions per week for 8 weeks using an upright exercise cycle.
Exercise Cycle
Exercise regimen: three monitored exercise sessions per week for eight weeks using the upright exercise cycle.
Interventions
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Exercise Cycle
Exercise regimen: three monitored exercise sessions per week for eight weeks using the upright exercise cycle.
Land-based Treadmill
Exercise regimen: three monitored exercise sessions per week for eight weeks using the land-based treadmill.
Water-based Treadmill
Exercise regimen: three monitored exercise sessions per week for eight weeks using the water-based treadmill.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Knee pain
* Radiographically confirmed knee osteoarthritis
Exclusion Criteria
* Inability to exercise via treadmill or exercise cycle
* Contraindication to radiography
* Pregnancy
* History of recent joint injection (steroid, synvisc, etc.) within 6 weeks of study
* History of previous joint arthroplasty
* History of inflammatory joint disease
* Inability to sign informed consent
30 Years
60 Years
ALL
No
Sponsors
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Milton S. Hershey Medical Center
OTHER
Responsible Party
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April Armstrong
Associate Professor
Principal Investigators
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Matthew Silvis, MD
Role: PRINCIPAL_INVESTIGATOR
Milton S. Hershey Medical Center
Locations
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Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
Countries
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References
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Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, O'Brien WL, Bassett DR Jr, Schmitz KH, Emplaincourt PO, Jacobs DR Jr, Leon AS. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000 Sep;32(9 Suppl):S498-504. doi: 10.1097/00005768-200009001-00009.
Bartels EM, Lund H, Hagen KB, Dagfinrud H, Christensen R, Danneskiold-Samsoe B. Aquatic exercise for the treatment of knee and hip osteoarthritis. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD005523. doi: 10.1002/14651858.CD005523.pub2.
Bosomworth NJ. Exercise and knee osteoarthritis: benefit or hazard? Can Fam Physician. 2009 Sep;55(9):871-8.
Cottrell E, Roddy E, Foster NE. The attitudes, beliefs and behaviours of GPs regarding exercise for chronic knee pain: a systematic review. BMC Fam Pract. 2010 Jan 18;11:4. doi: 10.1186/1471-2296-11-4.
Dunlop DD, Semanik P, Song J, Sharma L, Nevitt M, Jackson R, Mysiw J, Chang RW; Osteoarthritis Initiative Investigators. Moving to maintain function in knee osteoarthritis: evidence from the osteoarthritis initiative. Arch Phys Med Rehabil. 2010 May;91(5):714-21. doi: 10.1016/j.apmr.2010.01.015.
Dunn AL, Jewell JS. The effect of exercise on mental health. Curr Sports Med Rep. 2010 Jul-Aug;9(4):202-7. doi: 10.1249/JSR.0b013e3181e7d9af.
Ettinger WH Jr, Burns R, Messier SP, Applegate W, Rejeski WJ, Morgan T, Shumaker S, Berry MJ, O'Toole M, Monu J, Craven T. A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST). JAMA. 1997 Jan 1;277(1):25-31.
Fransen M, McConnell S. Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD004376. doi: 10.1002/14651858.CD004376.pub2.
Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, Macera CA, Heath GW, Thompson PD, Bauman A. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc. 2007 Aug;39(8):1423-34. doi: 10.1249/mss.0b013e3180616b27.
Heckman GA, McKelvie RS. Cardiovascular aging and exercise in healthy older adults. Clin J Sport Med. 2008 Nov;18(6):479-85. doi: 10.1097/JSM.0b013e3181865f03.
Helmick CG, Felson DT, Lawrence RC, Gabriel S, Hirsch R, Kwoh CK, Liang MH, Kremers HM, Mayes MD, Merkel PA, Pillemer SR, Reveille JD, Stone JH; National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 2008 Jan;58(1):15-25. doi: 10.1002/art.23177.
KELLGREN JH, LAWRENCE JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957 Dec;16(4):494-502. doi: 10.1136/ard.16.4.494. No abstract available.
Hunter DJ, McDougall JJ, Keefe FJ. The symptoms of osteoarthritis and the genesis of pain. Rheum Dis Clin North Am. 2008 Aug;34(3):623-43. doi: 10.1016/j.rdc.2008.05.004.
Kotlarz H, Gunnarsson CL, Fang H, Rizzo JA. Insurer and out-of-pocket costs of osteoarthritis in the US: evidence from national survey data. Arthritis Rheum. 2009 Dec;60(12):3546-53. doi: 10.1002/art.24984.
Lange AK, Vanwanseele B, Fiatarone Singh MA. Strength training for treatment of osteoarthritis of the knee: a systematic review. Arthritis Rheum. 2008 Oct 15;59(10):1488-94. doi: 10.1002/art.24118.
Lee IM. Physical activity and cardiac protection. Curr Sports Med Rep. 2010 Jul-Aug;9(4):214-9. doi: 10.1249/JSR.0b013e3181e7daf1.
Roddy E, Zhang W, Doherty M. Aerobic walking or strengthening exercise for osteoarthritis of the knee? A systematic review. Ann Rheum Dis. 2005 Apr;64(4):544-8. doi: 10.1136/ard.2004.028746.
Schiphof D, Boers M, Bierma-Zeinstra SM. Differences in descriptions of Kellgren and Lawrence grades of knee osteoarthritis. Ann Rheum Dis. 2008 Jul;67(7):1034-6. doi: 10.1136/ard.2007.079020. Epub 2008 Jan 15.
Whaley MH, Brubaker PH, Otto RM. ACSM's Guidelines for Exercise Testing and Prescription, 7th edition. USA: Lippincott Williams and Wilkins, 2006, pgs. 77-78, 146.
Wyatt FB, Milam S, Manske RC, Deere R. The effects of aquatic and traditional exercise programs on persons with knee osteoarthritis. J Strength Cond Res. 2001 Aug;15(3):337-40.
Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Rheum Dis Clin North Am. 2008 Aug;34(3):515-29. doi: 10.1016/j.rdc.2008.05.007.
Other Identifiers
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IRB#35938
Identifier Type: -
Identifier Source: org_study_id