Study Assessing Double-masked Uveitis Treatment

NCT ID: NCT01358266

Last Updated: 2019-07-16

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

592 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2016-12-31

Brief Summary

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The purpose of this study is to evaluate the safety and efficacy of intravitreal injections of DE-109 ophthalmic solution.

Detailed Description

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Conditions

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Uveitis; Posterior, Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Ophthalmic solution low dose

Group Type ACTIVE_COMPARATOR

DE-109 44 ug

Intervention Type DRUG

Low dose

Ophthalmic solution medium dose

Group Type ACTIVE_COMPARATOR

DE-109 440 ug

Intervention Type DRUG

Medium dose

Ophthalmic solution high dose

Group Type ACTIVE_COMPARATOR

DE-109 880 ug

Intervention Type DRUG

High dose

Interventions

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DE-109 44 ug

Low dose

Intervention Type DRUG

DE-109 440 ug

Medium dose

Intervention Type DRUG

DE-109 880 ug

High dose

Intervention Type DRUG

Other Intervention Names

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Sirolimus Sirolimus Sirolimus

Eligibility Criteria

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Inclusion Criteria

* Confirmed diagnosis of active uveitis
* 18 years of age or older
* Sign informed consent
* Meet best corrected ETDRS visual acuity

Exclusion Criteria

* Uveitis of infectious etiology
* Suspected/confirmed central nervous system or ocular lymphoma
* Primary diagnosis of anterior uveitis
* Uncontrolled glaucoma
* Use of topical oculary medication
* Implanted device
* Significant ocular disease
* Lens/media opacities or obscured ocular media
* Intraocular surgery or treatments
* Capsulotomy
* Ocular or periocular infection
* Pupillary dilation
* History of herpetic infection
* Toxoplasmosis or toxoplasmosis scar
* Ocular malignancy
* Allergy or hypersensitivity to study drug
* Participation in other uveitis trial within 30 days
* Monoclonal antibody treatment or biologic therapy
* Any systemic condition/infection
* Immunosuppressive therapy or immunocompromised
* Malignancy remission
* Females who are pregnant or lactating and females not using adequate contraceptives
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Santen Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Abu Abraham, MD

Role: STUDY_DIRECTOR

Santen Inc.

Locations

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Phoenix, Arizona, United States

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Tucson, Arizona, United States

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Beverly Hills, California, United States

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Loma Linda, California, United States

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Los Angeles, California, United States

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Mountain View, California, United States

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Sacramento, California, United States

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Torrance, California, United States

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Aurora, Colorado, United States

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Colorado Springs, Colorado, United States

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Golden, Colorado, United States

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Altamonte Springs, Florida, United States

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Jacksonville, Florida, United States

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Miami, Florida, United States

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Orlando, Florida, United States

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Pensacola, Florida, United States

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Tampa, Florida, United States

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Winter Haven, Florida, United States

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Augusta, Georgia, United States

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Chicago, Illinois, United States

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Oak Park, Illinois, United States

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Indianapolis, Indiana, United States

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Iowa City, Iowa, United States

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Wichita, Kansas, United States

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Baltimore, Maryland, United States

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Boston, Massachusetts, United States

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Cambridge, Massachusetts, United States

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Peabody, Massachusetts, United States

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Ann Arbor, Michigan, United States

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Grand Rapids, Michigan, United States

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Jackson, Michigan, United States

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Royal Oak, Michigan, United States

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Southfield, Michigan, United States

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Edina, Minnesota, United States

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St Louis, Missouri, United States

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Missoula, Montana, United States

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Lincoln, Nebraska, United States

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Omaha, Nebraska, United States

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Portsmouth, New Hampshire, United States

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New Brunswick, New Jersey, United States

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Newark, New Jersey, United States

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Northfield, New Jersey, United States

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Teaneck, New Jersey, United States

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Toms River, New Jersey, United States

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Albany, New York, United States

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New York, New York, United States

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Orchard Park, New York, United States

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Rochester, New York, United States

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Slingerlands, New York, United States

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Southern Pines, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Cleveland, Ohio, United States

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Eugene, Oregon, United States

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Camp Hill, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Reading, Pennsylvania, United States

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West Mifflin, Pennsylvania, United States

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Columbia, South Carolina, United States

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Ladson, South Carolina, United States

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Rapid City, South Dakota, United States

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Knoxville, Tennessee, United States

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Arlington, Texas, United States

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Austin, Texas, United States

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Dallas, Texas, United States

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Fort Worth, Texas, United States

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Houston, Texas, United States

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McAllen, Texas, United States

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San Antonio, Texas, United States

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Salt Lake City, Utah, United States

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Burlington, Vermont, United States

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Richmond, Virginia, United States

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Virginia Beach, Virginia, United States

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Milwaukee, Wisconsin, United States

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Buenos Aires, , Argentina

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Mendoza, , Argentina

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Olivos, , Argentina

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Pilar, , Argentina

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Rosario, , Argentina

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San Juan Bautista, , Argentina

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Graz, , Austria

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Klagenfurt, , Austria

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Americana, , Brazil

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Araraquara, , Brazil

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Londrina, , Brazil

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Recife, , Brazil

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Rio de Janeiro, , Brazil

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São Paulo, , Brazil

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Sorocaba, , Brazil

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Santiago, , Chile

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Bogotá, , Colombia

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Cali, , Colombia

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Floridablanca, , Colombia

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Medellín, , Colombia

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Marseille, , France

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Nantes, , France

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Paris, , France

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Berlin, , Germany

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Cologne, , Germany

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Freiburg im Breisgau, , Germany

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Heidelberg, , Germany

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München, , Germany

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Münster, , Germany

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Tübingen, , Germany

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Ahmedabad, , India

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Bangalore, , India

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Bhubaneshwar, , India

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Chennai, , India

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Hyderabad, , India

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Kolkata, , India

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Madurai, , India

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Mumbai, , India

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New Delhi, , India

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Noida, , India

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Afula, , Israel

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Beersheba, , Israel

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Haifa, , Israel

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Jerusalem, , Israel

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Petah Tikva, , Israel

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Ramat Gan, , Israel

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Rehovot, , Israel

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Tel Aviv, , Israel

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Bologna, , Italy

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Florence, , Italy

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Milan, , Italy

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Padua, , Italy

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Pisa, , Italy

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Reggio Emilia, , Italy

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Hokkaido, , Japan

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Osaka, , Japan

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Sapporo, , Japan

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Sendai, , Japan

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Tokyo, , Japan

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Lima, , Peru

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Trujillo, , Peru

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Lodz, , Poland

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Lublin, , Poland

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Poznan, , Poland

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Wroclaw, , Poland

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Alicante, , Spain

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Barcelona, , Spain

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Madrid, , Spain

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Santiago de Compostela, , Spain

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Torrevieja, , Spain

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Ankara, , Turkey (Türkiye)

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Istanbul, , Turkey (Türkiye)

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Izmir, , Turkey (Türkiye)

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Belfast, , United Kingdom

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Bradford, , United Kingdom

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Bristol, , United Kingdom

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London, , United Kingdom

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Countries

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United States Argentina Austria Brazil Chile Colombia France Germany India Israel Italy Japan Peru Poland Spain Turkey (Türkiye) United Kingdom

Other Identifiers

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32-007

Identifier Type: -

Identifier Source: org_study_id

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