The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume

NCT ID: NCT01344265

Last Updated: 2013-04-04

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 46 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-06-30
• Study Completion Date: 2011-10-31

Brief Summary

The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.

Conditions

Critically Ill

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

consecutive patients

there is only one group in our study

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• critically ill patients who required hemodynamic monitoring using PiCCO

Exclusion Criteria

• patients with renal dysfunction
• those older than 80 years
• pregnant women

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Jinhua Central Hospital

OTHER

Sponsor Role: lead

Responsible Party

Zhongheng Zhang

Dr.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Zhongheng Zhang, MD

Role: STUDY_CHAIR

Jinhua Central Hospital

Locations

Jinhua central hospital

Jinhua, Zhejiang, China

Countries

China

Other Identifiers

zh_zhang1984

Identifier Type: -

Identifier Source: org_study_id