Study of Pazopanib in the Treatment of Surgically Unresectable or Metastatic Chondrosarcoma

NCT ID: NCT01330966

Last Updated: 2023-03-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 47 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2011-04-30
• Study Completion Date: 2018-02-28

Brief Summary

The purpose of this study is to determine the effectiveness and safety of single agent pazopanib in subjects with chondrosarcoma.

Detailed Description

This research study is being conducted in adult subjects with a type of bone cancer called chondrosarcoma that has spread to other parts of the body and is not able to be removed with surgery. There is only one study drug that will be used in this study. It is a drug that interferes with cell communication and growth, taken orally. The study drug is called pazopanib.

Conditions

Chondrosarcoma; Metastatic Chondrosarcoma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

pazopanib

Pazopanib 800 mg orally once daily will be started on Cycle 1 Day 1 and will be administered continuously for a 28-day cycle.

Group Type: EXPERIMENTAL

pazopanib

Intervention Type: DRUG

Pazopanib 800 mg orally once daily will be started on Cycle 1 Day 1 and will be administered continuously for a 28-day cycle.

Interventions

pazopanib

Pazopanib 800 mg orally once daily will be started on Cycle 1 Day 1 and will be administered continuously for a 28-day cycle.

Intervention Type: DRUG

Other Intervention Names

Votrient

Eligibility Criteria

Inclusion Criteria

• Written informed consent.
• Age > or = to 18 years.
• Histologically confirmed diagnosis of conventional chondrosarcoma of any grade.
• Surgically unresectable or metastatic disease.
• Any number of prior treatment regimens, including treatment naive subjects. Prior treatment with tyrosine kinase inhibitors is permitted.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2.
• Measurable or evaluable (non-measurable) disease per RECIST guidelines version 1.1.
• Adequate organ system function determined within 14 days prior to first dose of study treatment.
• Left ventricular ejection fraction > 50% or the institutional LLN within 28 days prior to the first dose of study treatment.
• Females must either be of non-child bearing potential or have a negative serum pregnancy test within 7 days prior to the first dose of study treatment.

Exclusion Criteria

• Prior treatment with pazopanib.
• Mesenchymal, dedifferentiated, and extraskeletal myxoid chondrosarcoma subtypes.
• Prior malignancy (Note: subjects who have had another malignancy and have been disease-free for 3 years, or subjects with a history of completely resected non-melanomatous skin carcinoma or successfully treated in situ carcinoma are eligible).
• History or clinical evidence of central nervous system (CNS) metastases or leptomeningeal carcinomatosis, unless previously treated, asymptomatic, and off steroids and anti-seizure medication for 6 months prior to first dose of study drug.
• Clinically significant gastrointestinal (GI) abnormalities that may increase the risk for GI bleeding.
• Clinically significant GI abnormalities that may affect absorption of investigational product.
• Presence of uncontrolled infection.
• Corrected QT interval > 480 msecs using Bazett's formula.
• History of certain cardiovascular conditions within the past 6 months.
• Poorly controlled hypertension [defined as systolic blood pressure of > or = 140 mmHg or diastolic blood pressure of > or = 90 mmHg].
• History of cerebrovascular accident including transient ischemic attack, pulmonary embolism, or untreated deep venous thrombosis within the past 6 months.
• Prior major surgery or trauma within 28 days prior to the first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer.
• Evidence of active bleeding or bleeding diathesis.
• Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage.
• Hemoptysis in excess of 2.5 mL within 8 weeks of first dose of study drug.
• Any serious and/or unstable pre-existing medical, psychiatric, or other condition that could interfere with subject's safety, provision of informed consent, or compliance to study procedures.
• Unable or unwilling to discontinue use of prohibited medications for at least 14 days or five half-lives of a drug (whichever is longer) prior to the first dose of study drug and for the duration of study treatment.
• Radiation therapy, surgery (except major surgery), tumor embolization, chemotherapy, immunotherapy, biologic therapy, investigational therapy, or hormonal therapy within 14 days or five half-lives of a drug (whichever is longer) prior to the first dose of study drug.
• Any ongoing toxicity from prior anti-cancer therapy that is > Grade 1 and/or that is progressing in severity, except alopecia.
• Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to pazopanib or excipients that contraindicates participation.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

GlaxoSmithKline

INDUSTRY

Sponsor Role: collaborator

Emerald Clinical Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Arthur Staddon, MD

Role: STUDY_CHAIR

Pennsylvania Oncology Hematology Associates

Warren Chow, MD

Role: STUDY_CHAIR

City of Hope Medical Center

Locations

City of Hope

Duarte, California, United States

Edward Cancer Center

Naperville, Illinois, United States

University of Iowa

Iowa City, Iowa, United States

Mayo Clinic

Rochester, Minnesota, United States

Pennsylvania Oncology Hematology Associates

Philadelphia, Pennsylvania, United States

MD Anderson

Houston, Texas, United States

University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre

Edgbaston, Birmingham, United Kingdom

Countries

United States; United Kingdom

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

AAPSMCS1002

Identifier Type: -

Identifier Source: org_study_id