Evolution of Cellular and Viral Resistance in HIV-infected Patients With Lymphoma

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-05-31

Study Completion Date

2014-05-31

Brief Summary

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The study's chief objective is to observe the evolution of cellular (in terms of expression of transmembrane transporters and their transcriptional regulators) and viral resistance (in terms of development of mutations in the HIV genome that may confer resistance to future treatment for HIV) in HIV-infected patients with lymphoma.

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Detailed Description

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The study team will take two or three tubes of blood on three occasions during the course of chemotherapy. The total amount of blood required for this research project is 64mL (approximately 4 tablespoons).

This will allow better understanding of the changes that take place in the blood and the HIV virus itself. It is hoped that this will provide new insights that may aid the understanding and treatment of HIV patients with lymphoma.

Conditions

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HIV Lymphoma

Study Design

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Observational Model Type

CASE_CONTROL

Study Groups

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HIV patients without lymphoma

HIV-infected subjects on cART without a diagnosis of lymphoma

No interventions assigned to this group

HIV patients with lymphoma

HIV seropositive individuals with lymphoma

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* The ability to understand and sign a written informed consent form, prior to participation in any screening procedure and must be willing to comply with all study requirements.
* Documented HIV-1 infection.
* Diagnosis of lymphoma (with the exclusion of the five subjects that will be controls).
* On cART or about to start cART as part of clinical routine care before the initiation of chemotherapy.