Phospholipid Absorption of a Milk Phospholipid

NCT ID: NCT01327430

Last Updated: 2011-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-05-31

Study Completion Date

2010-06-30

Brief Summary

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The aim of the study is to investigate parameters of the lipid metabolism in plasma and feces of healthy subjects after a dietary supplementation of different dosages of milk phospholipids.

Detailed Description

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To date the mechanisms for the intestinal absorption of glycerophosphates and sphingolipids are not completely investigated. It is assumed, that sphingolipids and sterols compete for intestinal absorption. In addition it is unclear, if a dietary phospholipid supplementation may influence the phospholipid concentration in plasma.

To evaluate the effect of a dietary phospholipid supplementation 15 healthy female subjects received over 10 days daily 3 g of milk phospholipids stirred in a dairy product. During the following 10 days the subjects were supplemented with daily 6 g milk phospholipid. Finally, the subjects received over 10 days 6 g of the milk phospholipid in a dairy product and 2 g of plant sterols serving a commercial product.

Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Phospholipid supplementation

Supplementation of milk phospholipid

Group Type EXPERIMENTAL

Milk phospholipid

Intervention Type DIETARY_SUPPLEMENT

During day 1 until 10 the subjects were supplemented with daily 3 g milk phospholipids, during the day 11 and 20 the supplementation was increased to daily 6 g, and during the day 21 and 30 the subjects received daily 6 g milk phospholipids and 2 g of plant sterols.

Interventions

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Milk phospholipid

During day 1 until 10 the subjects were supplemented with daily 3 g milk phospholipids, during the day 11 and 20 the supplementation was increased to daily 6 g, and during the day 21 and 30 the subjects received daily 6 g milk phospholipids and 2 g of plant sterols.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* female
* age: between 30 and 45 years

Exclusion Criteria

* metabolic diseases
* arteriosclerosis
* pregnancy and breast feeding
Minimum Eligible Age

30 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Jena

OTHER

Sponsor Role lead

Responsible Party

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Friedrich Schiller University of Jena, Department of Nutritional Physiology

Principal Investigators

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Gerhard Jahreis, Prof. Dr.

Role: PRINCIPAL_INVESTIGATOR

Friedrich Schiller University, Department of Nutritional Physiology

Locations

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Friedrich Schiller University of Jena, Department of Nutritional Physiology

Jena, Thuringia, Germany

Site Status

Countries

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Germany

References

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Keller S, Malarski A, Reuther C, Kertscher R, Kiehntopf M, Jahreis G. Milk phospholipid and plant sterol-dependent modulation of plasma lipids in healthy volunteers. Eur J Nutr. 2013 Apr;52(3):1169-79. doi: 10.1007/s00394-012-0427-0. Epub 2012 Jul 27.

Reference Type DERIVED
PMID: 22836514 (View on PubMed)

Other Identifiers

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LSEP H44-10

Identifier Type: -

Identifier Source: org_study_id

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