Systemic Inflammation Versus Acute Pain in Total Knee Arthroplasty (TKA)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-08-31

Study Completion Date

2011-10-31

Brief Summary

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In this study we evaluate if there is a correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA).

Detailed Description

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The correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA) is evaluated.

Level of systemic inflammatory markers (CRP and IL6) are measured preoperatively and 4 and 24 hours postoperatively. These measurements are correlated to postoperative pain (a detailed assessment of pain at rest and during ambulation).

We pole blood-samples collected prospectively (from two data set)

Conditions

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Other Acute Postoperative Pain Systemic Inflammatory Response Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Total knee arthroplasty

Patients operated with elective, unilateral total knee arthroplasty.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Elective unilateral primary total knee arthroplasty
* Able to speak and understand danish
* Able to give informed consent

Exclusion Criteria

* Alcohol or medical abuse
* Allergies to local anesthetics or methylprednisolone
* Age \< 18 years old
* Daily use of strong opioids or glucocorticoids
* Pregnancy or breastfeeding (fertile women)
* Bilateral / revision arthroplasty
* Dementia or other cognitive dysfunction
* Diabetic neuropathy, rheumatoid arthritis, and neurologic or psychiatric diseases potentially influencing pain perception

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Troels Haxholdt Lunn

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Dep. of Anesthsiology, Hvidovre University Hospital

Copenhagen, Hvidovre, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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9991999

Identifier Type: -

Identifier Source: org_study_id