The Effects of Homogenized and Unhomogenized Milk on Postprandial Metabolism in Healthy Overweight Men
NCT ID: NCT01317524
Last Updated: 2011-12-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
18 participants
INTERVENTIONAL
2011-02-28
2011-06-30
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
SINGLE
Study Groups
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Homogenized Milk
900 mL homogenized milk is consumed within a mixed meal
Homogenized milk
900 mL homogenized milk 2 slices of bread with marmalade 2 pieces of crisp bread
Unhomogenized Milk
900 mL unhomogenized milk is consumed within a mixed meal
Unhomogenized milk
900 mL unhomogenized milk 2 slices of bread with marmalade 2 pieces of crisp bread
Skimmed Milk
900 mL skimmed milk and 44 g of butter are consumed within a mixed meal
Skimmed Milk
900 mL skimmed milk 44 g of salted butter 2 slices of bread 2 pieces of crisp bread
Interventions
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Homogenized milk
900 mL homogenized milk 2 slices of bread with marmalade 2 pieces of crisp bread
Unhomogenized milk
900 mL unhomogenized milk 2 slices of bread with marmalade 2 pieces of crisp bread
Skimmed Milk
900 mL skimmed milk 44 g of salted butter 2 slices of bread 2 pieces of crisp bread
Eligibility Criteria
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Inclusion Criteria
* aged between 18 and 70 years
* Quetelet index between 25 - 30 kg/m2
* mean serum triacylglycerol (≤1.7 mmol/L (31))
Exclusion Criteria
* indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus (32)
* lactose intolerance
* current smoker
* familial hypercholesterolemia
* abuse of drugs
* more than 21 alcoholic consumptions per week
* no stable body weight (weight gain or loss \< 3 kg in the past three months)
* use of medication or a diet known to affect serum lipid or glucose metabolism
* severe medical conditions that might interfere with the study, such as epilepsy, asthma, chronic obstructive pulmonary disease, inflammatory bowel diseases and rheumatoid arthritis.
* active cardiovascular disease like congestive heart failure or recent (\<6 months) event (acute myocardial infarction, cerebro vascular accident)
* use of an investigational product within the previous 1 month
* not willing to stop the consumption of vitamin supplements, fish oil capsules or products rich in plant stanol or sterol esters 3 weeks before the start of the study
* not willing to give up being a blood donor (or having donated blood) from 8 weeks before the start of the study and during the study
* difficult venipuncture as evidenced during the screening visits
18 Years
70 Years
MALE
Yes
Sponsors
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Dutch Dairy Association (NZO)
UNKNOWN
Maastricht University Medical Center
OTHER
Responsible Party
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Principal Investigators
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Ronald P Mensink, PhD.
Role: PRINCIPAL_INVESTIGATOR
Maastricht University Medical Center
Locations
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Maastricht University Medical Center
Maastricht, Limburg, Netherlands
Countries
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Other Identifiers
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MEC 10-3-089
Identifier Type: -
Identifier Source: org_study_id