GSK1605786A in the Maintenance of Remission in Subjects With Crohn's Disease

NCT ID: NCT01316939

Last Updated: 2017-09-07

Study Results

Results available

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

229 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-09

Study Completion Date

2013-10-23

Brief Summary

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A randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of two doses (500 mg once daily and 500 mg twice daily) of GSK1605786A in maintaining remission over 52 weeks in adult subjects with Crohn's disease. Efficacy will be assessed by the Crohn's Disease Activity Index (CDAI) score. Eligible subjects will have achieved response (CDAI decrease of at least 100 points) and/or remission (CDAI less than 150) in a prior GSK sponsored induction study. The primary endpoint will be proportion of subjects in remission at both Weeks 28 and 52. Safety will be assessed by recording of adverse events, clinical laboratory parameters including liver function tests, vital signs and electrocardiogram. Population pharmacokinetics will evaluate the two doses of GSK1605786A. Health outcomes assessments will include changes in Inflammatory Bowel Disease Questionnaire (IBDQ), SF-36v2, EQ-5D, Work Productivity and Activity Impairment - Crohn's Disease (WPAI-CD) and disability.

Detailed Description

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This is a multi-centre, randomised, placebo-controlled, double-blind parallel group study in adult subjects with Crohn's disease who previously achieved clinical response (CDAI decrease of at least 100 points) and/or remission (CDAI less than 150) in a prior Phase III induction study (Study CCX114151 or another GSK sponsored induction study). Subjects will be randomised to 52 weeks of oral treatment with GSK1605786A 500 mg once daily or 500 mg twice daily or placebo. Subjects who are receiving concomitant corticosteroids at entry will undergo dose tapering following a defined schedule. Subjects who complete the treatment period may be eligible to enter an open-label extension study. Subjects who experience disease worsening and require additional (rescue) treatment will be withdrawn and may be eligible to enter the open-label study. Subjects who do not enter the open-label study must complete a follow-up assessment 4 weeks after completion of treatment. Approximately 756 subjects will be enrolled.

Conditions

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Crohn's Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo

GSK1605786A once daily

500 milligrams once daily

Group Type EXPERIMENTAL

GSK1605786A

Intervention Type DRUG

GSK1605786A 500 milligrams once daily

GSK1605786A twice daily

500 milligrams twice daily

Group Type EXPERIMENTAL

GSK1605786A

Intervention Type DRUG

GSK1605786A 500 milligrams twice daily

Interventions

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GSK1605786A

GSK1605786A 500 milligrams once daily

Intervention Type DRUG

Placebo

Placebo

Intervention Type DRUG

GSK1605786A

GSK1605786A 500 milligrams twice daily

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subjects achieving clinical response (CDAI decrease of at least 100 points) and/or remission (CDAI less than 150) upon completion of treatment in Study CCX114151 or another GSK sponsored induction study
* Written informed consent prior to any CCX114157 specific study procedures
* Females of child-bearing potential must be sexually inactive or commit to use of consistent and correct use of contraceptive methods with a failure rate of less than 1 percent
* Stable doses of Crohn's disease medications
* Subjects on corticosteroids at entry must be willing to undergo corticosteroid dose taper during the study

Exclusion Criteria

* If female, is pregnant, has a positive pregnancy test or is breast-feeding
* Subjects with known or suspected coeliac disease or a positive screening test (anti-tissue transglutaminase antibodies) should have been excluded from enrolment into the induction studies. Subjects in whom a diagnosis of coeliac disease is subsequently suspected should have this excluded with testing for anti-tissue transglutaminase antibodies prior to enrolment into the maintenance study.
* Known or suspected fixed symptomatic small bowel stricture
* Enterocutaneous, abdominal or pelvic fistulae likely to require surgery during the study period
* Current sepsis or infections requiring intravenous antibiotic therapy for greater than 2 weeks
* Evidence of hepatic dysfunction, viral hepatitis, or liver function abnormalities
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GlaxoSmithKline

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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GSK Clinical Trials

Role: STUDY_DIRECTOR

GlaxoSmithKline

Locations

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GSK Investigational Site

Little Rock, Arizona, United States

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Tucson, Arizona, United States

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La Jolla, California, United States

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San Diego, California, United States

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San Francisco, California, United States

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Aurora, Colorado, United States

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Lakewood, Colorado, United States

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Littleton, Colorado, United States

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Hamden, Connecticut, United States

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New Haven, Connecticut, United States

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Washington D.C., District of Columbia, United States

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Jacksonville, Florida, United States

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Port Orange, Florida, United States

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Atlanta, Georgia, United States

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Suwanee, Georgia, United States

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Chicago, Illinois, United States

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Indianapolis, Indiana, United States

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Lexington, Kentucky, United States

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Hammond, Louisiana, United States

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Monroe, Louisiana, United States

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Chevy Chase, Maryland, United States

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Towson, Maryland, United States

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Towson, Maryland, United States

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Boston, Massachusetts, United States

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Ann Arbor, Michigan, United States

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Chesterfield, Michigan, United States

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Troy, Michigan, United States

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Rochester, Minnesota, United States

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Lee's Summit, Missouri, United States

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Mexico, Missouri, United States

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Brooklyn, New York, United States

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East Setauket, New York, United States

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Great Neck, New York, United States

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Lake Success, New York, United States

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Chapel Hill, North Carolina, United States

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Charlotte, North Carolina, United States

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Charlotte, North Carolina, United States

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Durham, North Carolina, United States

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Raleigh, North Carolina, United States

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Columbus, Ohio, United States

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Tulsa, Oklahoma, United States

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Portland, Oregon, United States

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Pittsburgh, Pennsylvania, United States

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Germantown, Tennessee, United States

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Nashville, Tennessee, United States

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Ogden, Utah, United States

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Christiansburg, Virginia, United States

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Danville, Virginia, United States

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Norfolk, Virginia, United States

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Richmond, Virginia, United States

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Seattle, Washington, United States

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Seattle, Washington, United States

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Madison, Wisconsin, United States

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Milwaukee, Wisconsin, United States

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Bankstown, New South Wales, Australia

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Hersten, Queensland, Australia

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Adelaide, South Australia, Australia

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Kurralta Park, South Australia, Australia

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Box Hill, Victoria, Australia

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Fitzroy, Victoria, Australia

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Prahran, Victoria, Australia

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Fremantle, Western Australia, Australia

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Hall in Tirol, , Austria

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Linz, , Austria

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Oberpullendorf, , Austria

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St.Veit/Glan, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Bonheiden, , Belgium

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Brussels, , Belgium

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Brussels, , Belgium

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Ghent, , Belgium

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Kortrijk, , Belgium

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Leuven, , Belgium

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Roeselare, , Belgium

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Plovdiv, , Bulgaria

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Sofia, , Bulgaria

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Sofia, , Bulgaria

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Sofia, , Bulgaria

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Varna, , Bulgaria

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Calgary, Alberta, Canada

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Edmonton, Alberta, Canada

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Abbotsford, British Columbia, Canada

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Vancouver, British Columbia, Canada

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Winnipeg, Manitoba, Canada

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Halifax, Nova Scotia, Canada

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Hamilton, Ontario, Canada

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Hamilton, Ontario, Canada

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Kingston, Ontario, Canada

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London, Ontario, Canada

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London, Ontario, Canada

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Ottawa, Ontario, Canada

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Montreal, Quebec, Canada

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Montreal, Quebec, Canada

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Québec, Quebec, Canada

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Québec, Quebec, Canada

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Viña del Mar, , Chile

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Hradec Králové, , Czechia

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Olomouc, , Czechia

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Ostrava - Vitkovice, , Czechia

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Prague, , Czechia

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Prague, , Czechia

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Prague, , Czechia

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Prague, , Czechia

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Aalborg, , Denmark

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Aarhus, , Denmark

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Herlev, , Denmark

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Hvidovre, , Denmark

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Odense, , Denmark

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Tallinn, , Estonia

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Tallinn, , Estonia

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Tartu, , Estonia

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Clichy, , France

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Lille, , France

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Nantes, , France

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Nice, , France

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Paris, , France

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Pessac, , France

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Saint-Priest-en-Jarez, , France

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Vandœuvre-lès-Nancy, , France

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Ulm, Baden-Wurttemberg, Germany

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Frankfurt am Main, Hesse, Germany

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Brinkum/Stuhr, Lower Saxony, Germany

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Hanover, Lower Saxony, Germany

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Minden, North Rhine-Westphalia, Germany

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Berlin, , Germany

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Berlin, , Germany

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Hamburg, , Germany

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Hamburg, , Germany

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Hong Kong, , Hong Kong

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Shatin, New Territories, , Hong Kong

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Békéscsaba, , Hungary

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Budapest, , Hungary

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Budapest, , Hungary

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Budapest, , Hungary

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Debrecen, , Hungary

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Mosonmagyaróvár, , Hungary

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Szekszárd, , Hungary

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Vác, , Hungary

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Afula, , Israel

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Beersheba, , Israel

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Haifa, , Israel

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Holon, , Israel

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Jerusalem, , Israel

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Jerusalem, , Israel

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Kfar Saba, , Israel

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Petah Tikva, , Israel

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Ramat Gan, , Israel

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Tel Aviv, , Israel

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Ẕerifin, , Israel

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Palermo, Sicily, Italy

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Genova, , Italy

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Modena, , Italy

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Roma, , Italy

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Roma, , Italy

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Aichi, , Japan

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Chiba, , Japan

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Fukuoka, , Japan

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Fukuoka, , Japan

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Hiroshima, , Japan

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Hokkaido, , Japan

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Hyōgo, , Japan

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Kagoshima, , Japan

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Kagoshima, , Japan

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Miyagi, , Japan

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Osaka, , Japan

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Osaka, , Japan

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Tokyo, , Japan

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Tokyo, , Japan

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Amsterdam, , Netherlands

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Amsterdam, , Netherlands

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Amsterdam, , Netherlands

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Ede, , Netherlands

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Eindhoven, , Netherlands

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Rotterdam, , Netherlands

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Rotterdam, , Netherlands

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Dunedin, , New Zealand

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Lower Hutt, , New Zealand

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Otahuhu, Auckland, , New Zealand

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Tauranga, , New Zealand

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Tromsø, , Norway

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Tønsberg, , Norway

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Bydgoszcz, , Poland

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Bydgoszcz, , Poland

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Lublin, , Poland

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Sopot, , Poland

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Torun, , Poland

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Wroclaw, , Poland

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Lisbon, , Portugal

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Lisbon, , Portugal

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Porto, , Portugal

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Viseu, , Portugal

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Irkutsk, , Russia

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Kazan', , Russia

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Lipetsk, , Russia

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Moscow, , Russia

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Nizhny Novgorod, , Russia

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Rostov-on-Don, , Russia

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Saint Petersburg, , Russia

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Saint Petersburg, , Russia

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Samara, , Russia

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Tomsk, , Russia

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Bratislava, , Slovakia

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Bratislava, , Slovakia

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Bratislava, , Slovakia

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Nitra, , Slovakia

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Nové Mesto nad Váhom, , Slovakia

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Prešov, , Slovakia

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Trnava, , Slovakia

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Bellville, , South Africa

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Claremont, , South Africa

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Observatory, , South Africa

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Parktown, , South Africa

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Daegu, , South Korea

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Pusan, , South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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Wŏnju, , South Korea

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Badalona, , Spain

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Elche, , Spain

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Fuenlabrada (Madrid), , Spain

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Galdakao/Vizcaya, , Spain

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Madrid, , Spain

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Madrid, , Spain

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Madrid, , Spain

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Madrid, , Spain

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Marbella, , Spain

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Sabadell (Barcelona), , Spain

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Santander (Cantabria), , Spain

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Lund, , Sweden

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Stockholm, , Sweden

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Stockholm, , Sweden

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Bern, , Switzerland

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Zurich, , Switzerland

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Taichung, , Taiwan

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Ankara, , Turkey (Türkiye)

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Chernivtsi, , Ukraine

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Dnipropetrovsk, , Ukraine

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Donetsk, , Ukraine

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Donetsk, , Ukraine

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Kharkiv, , Ukraine

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Kyiv, , Ukraine

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Odesa, , Ukraine

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Simferopol, , Ukraine

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Vinnytsia, , Ukraine

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Harrow, Middlesex, United Kingdom

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Birmingham, , United Kingdom

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Bristol, , United Kingdom

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Edinburgh, , United Kingdom

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Manchester, , United Kingdom

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Newcastle upon Tyne, , United Kingdom

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Oxford, , United Kingdom

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Salford, , United Kingdom

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Countries

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United States Australia Austria Belgium Bulgaria Canada Chile Czechia Denmark Estonia France Germany Hong Kong Hungary Israel Italy Japan Netherlands New Zealand Norway Poland Portugal Russia Slovakia South Africa South Korea Spain Sweden Switzerland Taiwan Turkey (Türkiye) Ukraine United Kingdom

Other Identifiers

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2010-022383-12

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

114157

Identifier Type: -

Identifier Source: org_study_id

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