Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
26 participants
INTERVENTIONAL
2010-08-31
2016-02-29
Brief Summary
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Study hypothesis
How is the brain activity of emotional processing and anxiety affected after completing an Internet-based CBT compared with computerized attention training? Does the treatment response of an Internet based treatment affects by variations in serotonin-transporter-linked promoter region (5-HTTLPR) and tryptophan hydroxylase-3 (TPH3) genes?
How is the genetic variations related to symptoms in social phobia (pre treatment)?
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
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Cognitive behavior therapy via the internet
Cognitive behavior therapy via the internet with therapist support.
Internet-based cognitive behavioural therapy (iCBT)
The Internet-based cognitive behavioural therapy (iCBT) consists of our structured self-help program lasting a total of nine active treatment weeks. This treatment program has been well evaluated and involved in several research projects.
Attentional retraining
Attentional retraining as described by Nader Amir.
Internet-based computerized attention training
The Internet-based computerized attention training program lasting a total of four active treatment weeks. The treatment is consist of two training sessions per week, about 10 minutes long.
Interventions
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Internet-based cognitive behavioural therapy (iCBT)
The Internet-based cognitive behavioural therapy (iCBT) consists of our structured self-help program lasting a total of nine active treatment weeks. This treatment program has been well evaluated and involved in several research projects.
Internet-based computerized attention training
The Internet-based computerized attention training program lasting a total of four active treatment weeks. The treatment is consist of two training sessions per week, about 10 minutes long.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* With fMRI the following criteria must not be filled: previous surgery in the heart or brain, metals implanted in the body, dental braces or bridge; piercings that can´t be taken out, tattoos (shoulders, arms and back is not so good, the legs are okay if it is not too large); trouble to lie still for about an hour, pregnancy or history of neurological diseases.
18 Years
ALL
No
Sponsors
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Uppsala University
OTHER
Umeå University
OTHER
Responsible Party
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Per Carlbring, PhD
Professor
Principal Investigators
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Per Carlbring, Professor
Role: STUDY_DIRECTOR
Umeå University
Gerhard Andersson, Professor
Role: STUDY_CHAIR
Linkoeping University
Tomas Furmark, Ass. professor
Role: STUDY_CHAIR
Uppsala University
Carl-Johan Olsson, Post doc
Role: STUDY_CHAIR
Umeå center for Functional Brain Imaging
Owe Bodlund, Ass. professor
Role: STUDY_CHAIR
NUS
Kristoffer NT Månsson, Student
Role: STUDY_CHAIR
Umeå University
Locations
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Department of Psychology, Umeå University
Umeå, Västerbotten County, Sweden
Countries
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References
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Mansson KN, Frick A, Boraxbekk CJ, Marquand AF, Williams SC, Carlbring P, Andersson G, Furmark T. Predicting long-term outcome of Internet-delivered cognitive behavior therapy for social anxiety disorder using fMRI and support vector machine learning. Transl Psychiatry. 2015 Mar 17;5(3):e530. doi: 10.1038/tp.2015.22.
Mansson KN, Salami A, Frick A, Carlbring P, Andersson G, Furmark T, Boraxbekk CJ. Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder. Transl Psychiatry. 2016 Feb 2;6(2):e727. doi: 10.1038/tp.2015.218.
Mansson KN, Carlbring P, Frick A, Engman J, Olsson CJ, Bodlund O, Furmark T, Andersson G. Altered neural correlates of affective processing after internet-delivered cognitive behavior therapy for social anxiety disorder. Psychiatry Res. 2013 Dec 30;214(3):229-37. doi: 10.1016/j.pscychresns.2013.08.012. Epub 2013 Sep 21.
Other Identifiers
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2010-185-31 M
Identifier Type: -
Identifier Source: org_study_id