"Quidel Reader Influenza A + B Test 510(k) and CLIA Waiver Field Study"

NCT ID: NCT01309568

Last Updated: 2011-05-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-02-28

Study Completion Date

2011-04-30

Brief Summary

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The objective of this study is to demonstrate the clinical performance of the Quidel Reader Influenza A+B test and Quidel Reader with the following sample types: nasal swab, nasopharyngeal swab, and nasopharyngeal aspirate/wash. Clinical performance will be based on comparison of Quidel Reader Influenza A+B results to cell culture at a Central Reference or Alternative Laboratory.

Detailed Description

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A sufficient number of subjects will be enrolled to achieve a required minimum of cell culture-positive specimens for each sample type, nasal swab, nasopharyngeal swab, and nasopharyngeal aspirate/wash.

* The 510(k) study will include combined results from all sites and require the following for all three sample types: a minimum of 50 fresh positive results for influenza A, and 30 fresh positive results for influenza B.
* The CLIA Waiver submission will include combined results from all sites for a total of 120 positive specimens for both influenza A and influenza B. The nasal swab will be the primary sample type planned for the CLIA Waiver submission. However, depending upon the prevalence of influenza, nasopharyngeal swab and/or nasopharyngeal aspirate/wash may also be submitted for CLIA Waiver.

Conditions

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Influenza

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Investigational testing

Pending the outcome of culture, the subject may be treated with an approved antiviral medication at the doctors discretion.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Male or Female, of all ages (assuming appropriate consent is obtained).
2. Must currently be exhibiting symptoms characteristic of influenza-like-illness (ILI).

For example:

1. Fever, ≥ 38º C (100º F), either at the time of the visit or onset within the past two (2) days.
2. Nasal congestion
3. Rhinorrhea
4. Sore throat
5. Cough
6. Headache
7. Myalgia
8. Malaise

Exclusion Criteria

1. Has undergone treatment with anti-influenza antivirals within the previous 7 days, including, for example, one or more of the following, but not be limited to Amantadine, Rimantadine, Ribavirin, Oseltamivir, Zanamivir or any other antiviral currently available in these classes.
2. Has been vaccinated by means of an influenza nasal spray/mist vaccine within the previous 7 days.
3. Unable to understand and consent to participation; for minors this includes parent or legal guardian.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Quidel Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Quidel Corporation

Principal Investigators

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John D Tamerius, PhD

Role: STUDY_DIRECTOR

Quidel Corporation

Locations

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La Costa Pediatrics

Carlsbad, California, United States

Site Status

Santo Nino Medical Clinic

Panorama City, California, United States

Site Status

La Jolla Pediatrics

San Diego, California, United States

Site Status

Complete Family Care

Northglenn, Colorado, United States

Site Status

Adriana Castro, MD

Miami, Florida, United States

Site Status

Teena Hughes, MD

Tampa, Florida, United States

Site Status

DuPage Family Medicine

Naperville, Illinois, United States

Site Status

Paul Janson, MD

Florence, Kentucky, United States

Site Status

Paul McLaughlin, MD

Mount Sterling, Kentucky, United States

Site Status

Kamakshi Neelkantan, MD

Edgewood, Maryland, United States

Site Status

Priority Care Pediatrics

Kansas City, Missouri, United States

Site Status

Robert Farron, DO

Far Rockaway, New York, United States

Site Status

Twelve Corners Pediatrics

Rochester, New York, United States

Site Status

Montrose Family Practice

Akron, Ohio, United States

Site Status

Norristown Family Physicians

Norristown, Pennsylvania, United States

Site Status

Dell's Children's Medical Center

Austin, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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CS-0138-01-A

Identifier Type: -

Identifier Source: org_study_id

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