Trial Outcomes & Findings for Discovery Elbow Long-Term Survivorship (NCT NCT01308463)

NCT ID: NCT01308463

Last Updated: 2017-05-01

Results Overview

This is the patient's perception of pain related to the operative elbow. Maximum pain score = 50 (worst) Minimum pain score = 0 (best)

Recruitment status

TERMINATED

Target enrollment

29 participants

Primary outcome timeframe

10 Years Post-op

Results posted on

2017-05-01

Participant Flow

Recruitment has been discontinued.

Participant milestones

Participant milestones
Measure
Discovery Elbow
This arm includes all subjects who underwent total elbow arthroplasty with the Discovery Total Elbow and entered the long-term survival study.
Overall Study
STARTED
29
Overall Study
6 Months
23
Overall Study
1 Year
21
Overall Study
2 Years
18
Overall Study
3 Years
17
Overall Study
4 Years
20
Overall Study
5 Years
20
Overall Study
6 Years
11
Overall Study
7 Years
12
Overall Study
8 Years
14
Overall Study
9 Years
11
Overall Study
10 Years
8
Overall Study
11 Years
8
Overall Study
12 Years
2
Overall Study
COMPLETED
0
Overall Study
NOT COMPLETED
29

Reasons for withdrawal

Reasons for withdrawal
Measure
Discovery Elbow
This arm includes all subjects who underwent total elbow arthroplasty with the Discovery Total Elbow and entered the long-term survival study.
Overall Study
Study Discontinued
23
Overall Study
Death
4
Overall Study
Revision
2

Baseline Characteristics

Discovery Elbow Long-Term Survivorship

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
Discovery Elbow
n=29 Participants
This arm includes all subjects who underwent total elbow arthroplasty with the Discovery Total Elbow and entered the long-term survival study.
Age, Categorical
<=18 years
0 Participants
n=5 Participants
Age, Categorical
Between 18 and 65 years
16 Participants
n=5 Participants
Age, Categorical
>=65 years
13 Participants
n=5 Participants
Sex: Female, Male
Female
22 Participants
n=5 Participants
Sex: Female, Male
Male
7 Participants
n=5 Participants
Region of Enrollment
United States
29 Participants
n=5 Participants
Hand Dominance
Ambidextrous
1 Participants
n=5 Participants
Hand Dominance
Left
2 Participants
n=5 Participants
Hand Dominance
Right
25 Participants
n=5 Participants
Hand Dominance
Unknown
1 Participants
n=5 Participants
Primary Diagnosis
Functional Deformity
1 Participants
n=5 Participants
Primary Diagnosis
Humeral Fracture
3 Participants
n=5 Participants
Primary Diagnosis
Osteoarthritis
2 Participants
n=5 Participants
Primary Diagnosis
Other
4 Participants
n=5 Participants
Primary Diagnosis
Rheumatoid Arthritis
11 Participants
n=5 Participants
Primary Diagnosis
Traumatic Arthritis
7 Participants
n=5 Participants
Primary Diagnosis
Unknown
1 Participants
n=5 Participants

PRIMARY outcome

Timeframe: 10 Years Post-op

Population: The number of participants analyzed in this section is reflective of the number of participants/elbows with the complete data required to calculate this score. This is different than the number reflected in participant flow which is indicative of the number of participants/elbows with any data during the given interval.

This is the patient's perception of pain related to the operative elbow. Maximum pain score = 50 (worst) Minimum pain score = 0 (best)

Outcome measures

Outcome measures
Measure
Discovery Elbow
n=9 Elbows
This arm includes all subjects who underwent total elbow arthroplasty with the Discovery Total Elbow and entered the long-term survival study.
Patient Derived American Shoulder and Elbow Society (ASES) Pain Score
5.3 units on a scale
Standard Deviation 6.8

PRIMARY outcome

Timeframe: 10 Years Post-op

Population: The number of participants analyzed in this section is reflective of the number of participants/elbows with the complete data required to calculate this score. This is different than the number reflected in participant flow which is indicative of the number of participants/elbows with any data during the given interval.

This is the patient's perception of function. The maximum score is 36 and the minimum score is 0. The maximum score represents maximum function.

Outcome measures

Outcome measures
Measure
Discovery Elbow
n=9 Elbows
This arm includes all subjects who underwent total elbow arthroplasty with the Discovery Total Elbow and entered the long-term survival study.
Patient Derived American Shoulder and Elbow Society (ASES) Function
25.1 units on a scale
Standard Deviation 8.8

PRIMARY outcome

Timeframe: 10 Years Post-op

Population: The number of participants analyzed in this section is reflective of the number of participants/elbows with the complete data required to calculate this score. This is different than the number reflected in participant flow which is indicative of the number of participants/elbows with any data during the given interval.

This is the patient's perception of satisfaction with the elbow replacement surgery. Maximum Score = 10 Minimum Score = 0 Maximum Score represents maximum satisfaction.

Outcome measures

Outcome measures
Measure
Discovery Elbow
n=9 Elbows
This arm includes all subjects who underwent total elbow arthroplasty with the Discovery Total Elbow and entered the long-term survival study.
Patient Derived American Shoulder and Elbow Society (ASES) Satisfaction
9.2 units on a scale
Standard Deviation 1.4

SECONDARY outcome

Timeframe: 10 years Post-op

Population: This analysis cannot be conducted due to the low number of cases available with 10 year data. There is not sufficient data to calculate survivorship. This study is being terminated since the product has been sold to another company.

The consented Patient will answer specific questions about their elbow replacement such as; if the elbow replacement has been removed

Outcome measures

Outcome data not reported

Adverse Events

Discovery Elbow

Serious events: 10 serious events
Other events: 0 other events
Deaths: 0 deaths

Serious adverse events

Serious adverse events
Measure
Discovery Elbow
n=29 participants at risk
This arm includes all subjects who underwent total elbow arthroplasty with the Discovery Total Elbow and entered the long-term survival study.
Infections and infestations
Infection in Operative Joint
3.4%
1/29 • Number of events 7
Skin and subcutaneous tissue disorders
Complex Laceration of Arm
3.4%
1/29 • Number of events 1
Surgical and medical procedures
Ulnar Bearing Loosening
3.4%
1/29 • Number of events 1
Surgical and medical procedures
Screw Loose from Bearing
3.4%
1/29 • Number of events 1
Surgical and medical procedures
Bushing Failure
3.4%
1/29 • Number of events 1
General disorders
Unspecified Events Leading to Death
13.8%
4/29 • Number of events 4
Surgical and medical procedures
TEA Revision
3.4%
1/29 • Number of events 1
Surgical and medical procedures
Revision - Loose Humeral Component
3.4%
1/29 • Number of events 1

Other adverse events

Adverse event data not reported

Additional Information

Kelly Francher

Zimmer Biomet

Phone: 574-371-9783

Results disclosure agreements

  • Principal investigator is a sponsor employee A publication which uses data in addition to the authors will be reviewed by all who have contributed data, and all of the contributors will be recognized. All publications will be reviewed by BIOMET at least 30 days prior to publication.
  • Publication restrictions are in place

Restriction type: OTHER