Trial Outcomes & Findings for Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval in Aphasia (NCT NCT01300624)
NCT ID: NCT01300624
Last Updated: 2015-06-09
Results Overview
Picture description task that include trained words.
Recruitment status
COMPLETED
Study phase
PHASE2
Target enrollment
11 participants
Primary outcome timeframe
pre-treatment, post-treatment and 3-months post-treatment (maintenance)
Results posted on
2015-06-09
Participant Flow
Participant milestones
| Measure |
Verb Network Strengthening Treatment
Treatment tasks involve the retrieval of nouns related to a target verb. For example, for the verb measure, participants would come up with people who measure and what they measure (e.g., carpenter/lumber, chef/sugar). They would then answer questions related to why, where, and when these things might occur (e.g., for carpenter/measure, they might say "to get the right length of board," (why) "at a construction site," (where) and "when building a house" (where). Cues and assistance are provided to the participants when they are unable to complete any given task. As the participants improve, cues are reduced.
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Overall Study
STARTED
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11
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Overall Study
COMPLETED
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11
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Overall Study
NOT COMPLETED
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0
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Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval in Aphasia
Baseline characteristics by cohort
| Measure |
Verb Network Strengthening Treatment
n=11 Participants
Treatment tasks involve the retrieval of nouns related to a target verb. For example, for the verb measure, participants would come up with people who measure and what they measure (e.g., carpenter/lumber, chef/sugar). They would then answer questions related to why, where, and when these things might occur (e.g., for carpenter/measure, they might say "to get the right length of board," (why) "at a construction site," (where) and "when building a house" (where). Cues and assistance are provided to the participants when they are unable to complete any given task. As the participants improve, cues are reduced.
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Age, Continuous
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63.9 years
STANDARD_DEVIATION 12.4 • n=5 Participants
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Sex: Female, Male
Female
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4 Participants
n=5 Participants
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Sex: Female, Male
Male
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7 Participants
n=5 Participants
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Region of Enrollment
United States
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11 participants
n=5 Participants
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Noun naming
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79.9 Percentage of correct naming
STANDARD_DEVIATION 12.3 • n=5 Participants
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Verb naming
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64.6 Percentage of correct naming
STANDARD_DEVIATION 18.2 • n=5 Participants
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Trained sentence probes
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20.4 Percentage correct sentence production
STANDARD_DEVIATION 13.3 • n=5 Participants
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Untrained sentence probe
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19.8 Percentage correct sentence production
STANDARD_DEVIATION 11.0 • n=5 Participants
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Complete Utterances in discourse
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39.7 Percentage of complete utterances
STANDARD_DEVIATION 1.9 • n=5 Participants
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Western Aphasia Battery
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75.9 units on a scale
STANDARD_DEVIATION 10.4 • n=5 Participants
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Communicative Effectiveness Ratings
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32.6 units on a scale
STANDARD_DEVIATION 65.3 • n=5 Participants
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PRIMARY outcome
Timeframe: pre-treatment, post-treatment and 3-months post-treatment (maintenance)Picture description task that include trained words.
Outcome measures
| Measure |
Verb Network Strengthening Treatment
n=11 Participants
Treatment tasks involve the retrieval of nouns related to a target verb. For example, for the verb measure, participants would come up with people who measure and what they measure (e.g., carpenter/lumber, chef/sugar). They would then answer questions related to why, where, and when these things might occur (e.g., for carpenter/measure, they might say "to get the right length of board," (why) "at a construction site," (where) and "when building a house" (where). Cues and assistance are provided to the participants when they are unable to complete any given task. As the participants improve, cues are reduced.
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Trained Sentence Probe
Pre-treatment
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20.4 percentage of correct sentences
Standard Deviation 13.3
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Trained Sentence Probe
Post-treatment
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58.8 percentage of correct sentences
Standard Deviation 33.9
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Trained Sentence Probe
3 months post-treatment (maintenance)
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56.0 percentage of correct sentences
Standard Deviation 29.9
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PRIMARY outcome
Timeframe: pre-treatment, post-treatment and 3-months post-treatment (maintenance)Picture description with sentences containing untrained words.
Outcome measures
| Measure |
Verb Network Strengthening Treatment
n=11 Participants
Treatment tasks involve the retrieval of nouns related to a target verb. For example, for the verb measure, participants would come up with people who measure and what they measure (e.g., carpenter/lumber, chef/sugar). They would then answer questions related to why, where, and when these things might occur (e.g., for carpenter/measure, they might say "to get the right length of board," (why) "at a construction site," (where) and "when building a house" (where). Cues and assistance are provided to the participants when they are unable to complete any given task. As the participants improve, cues are reduced.
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Untrained Sentence Probes
Pre-treatment
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19.8 percentage of correct sentences
Standard Deviation 11.0
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Untrained Sentence Probes
Post-treatment
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40.9 percentage of correct sentences
Standard Deviation 24.9
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Untrained Sentence Probes
3 months post-treatment (maintenance)
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43.0 percentage of correct sentences
Standard Deviation 27.5
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PRIMARY outcome
Timeframe: pre-treatment, post-treatment and 3-months post-treatment (maintenance)Sentence in discourse that were relevant to topic and syntactically correct
Outcome measures
| Measure |
Verb Network Strengthening Treatment
n=11 Participants
Treatment tasks involve the retrieval of nouns related to a target verb. For example, for the verb measure, participants would come up with people who measure and what they measure (e.g., carpenter/lumber, chef/sugar). They would then answer questions related to why, where, and when these things might occur (e.g., for carpenter/measure, they might say "to get the right length of board," (why) "at a construction site," (where) and "when building a house" (where). Cues and assistance are provided to the participants when they are unable to complete any given task. As the participants improve, cues are reduced.
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Complete Utterances in Discourse
Pre-treatment
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39.7 percentage of complete utterances
Standard Deviation 11.9
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Complete Utterances in Discourse
Post-treatment
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46.7 percentage of complete utterances
Standard Deviation 16.0
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Complete Utterances in Discourse
3 months post-treatment (maintenance)
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47.9 percentage of complete utterances
Standard Deviation 13.8
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SECONDARY outcome
Timeframe: pre-treatment and post-treatmentConfrontation naming of 162 objects
Outcome measures
| Measure |
Verb Network Strengthening Treatment
n=11 Participants
Treatment tasks involve the retrieval of nouns related to a target verb. For example, for the verb measure, participants would come up with people who measure and what they measure (e.g., carpenter/lumber, chef/sugar). They would then answer questions related to why, where, and when these things might occur (e.g., for carpenter/measure, they might say "to get the right length of board," (why) "at a construction site," (where) and "when building a house" (where). Cues and assistance are provided to the participants when they are unable to complete any given task. As the participants improve, cues are reduced.
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Noun Naming
Pre-treatment
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79.9 percentage of correct naming
Standard Deviation 12.3
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Noun Naming
Post-treatment
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85.1 percentage of correct naming
Standard Deviation 12.6
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SECONDARY outcome
Timeframe: pre-treatment and post-treatmentConfrontation of 100 action pictures
Outcome measures
| Measure |
Verb Network Strengthening Treatment
n=11 Participants
Treatment tasks involve the retrieval of nouns related to a target verb. For example, for the verb measure, participants would come up with people who measure and what they measure (e.g., carpenter/lumber, chef/sugar). They would then answer questions related to why, where, and when these things might occur (e.g., for carpenter/measure, they might say "to get the right length of board," (why) "at a construction site," (where) and "when building a house" (where). Cues and assistance are provided to the participants when they are unable to complete any given task. As the participants improve, cues are reduced.
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Verb Naming
Pre-treatment
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64.6 percentage of correct naming
Standard Deviation 18.2
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Verb Naming
Post-treatment
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74.2 percentage of correct naming
Standard Deviation 16.0
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SECONDARY outcome
Timeframe: pre-treatment and post-treatmentStandardized measure of aphasia severity
Outcome measures
| Measure |
Verb Network Strengthening Treatment
n=11 Participants
Treatment tasks involve the retrieval of nouns related to a target verb. For example, for the verb measure, participants would come up with people who measure and what they measure (e.g., carpenter/lumber, chef/sugar). They would then answer questions related to why, where, and when these things might occur (e.g., for carpenter/measure, they might say "to get the right length of board," (why) "at a construction site," (where) and "when building a house" (where). Cues and assistance are provided to the participants when they are unable to complete any given task. As the participants improve, cues are reduced.
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Western Aphasia Battery
Pre-treatment
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75.9 units on a scale
Standard Deviation 10.4
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Western Aphasia Battery
Post-treatment
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82.1 units on a scale
Standard Deviation 8.6
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SECONDARY outcome
Timeframe: pre-treatment, post-treatment and 3-months post-treatment (maintenance)This questionnaire (Lomas et al, 1989) was provided to persons who communicated with the treatment participant regularly (e.g., a spouse). They rated how well the participant was able to perform on 16 common communication tasks (e.g., participating in a conversation over coffee). They rated each scenario along a line that spanned between the two extremes of ability, from "not at all able" to "as able as before the stroke." The line was 100 mm. To score responses, the place where they bisected the line was measured. An average of their responses across the 16 questions was calculated.
Outcome measures
| Measure |
Verb Network Strengthening Treatment
n=9 Participants
Treatment tasks involve the retrieval of nouns related to a target verb. For example, for the verb measure, participants would come up with people who measure and what they measure (e.g., carpenter/lumber, chef/sugar). They would then answer questions related to why, where, and when these things might occur (e.g., for carpenter/measure, they might say "to get the right length of board," (why) "at a construction site," (where) and "when building a house" (where). Cues and assistance are provided to the participants when they are unable to complete any given task. As the participants improve, cues are reduced.
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Communicative Effectiveness Ratings
Pre-treatment
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32.6 units on a scale
Standard Deviation 9.7
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Communicative Effectiveness Ratings
Post-treatment
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65.3 units on a scale
Standard Deviation 11.2
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Communicative Effectiveness Ratings
3 months post-treatment (maintenance)
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58.3 units on a scale
Standard Deviation 15.6
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Adverse Events
Verb Network Strengthening Treatment
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Lisa Edmonds, PhD
Brain Rehabilitation Research Center, Malcom Randall VA, Gainesville, FL
Phone: 352.262.4465
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place