Safety and Pharmacokinetics Study of Human Monoclonal Antibody (FGI-101-1A6)

NCT ID: NCT01299142

Last Updated: 2011-02-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2011-10-31

Brief Summary

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The purpose of this study is to determine the safety and tolerability of the anti-TSG101 human monoclonal antibody (FGI-101-1A6)when administered intravenously to healthy volunteers.

Detailed Description

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Primary -

\- To compare the safety profile of a single intravenous administration of FGI-101-1A6 as compared with Placebo

Secondary

* To evaluate the pharmacokinetics (PK) of a singel intravenous administration of FGI-101-1A6
* To evaluate the immunogenicity of FGI-101-1A6

Conditions

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Influenza

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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FGI-101-1A6

Intervention: Drug-FGI-101-1A6

Group Type EXPERIMENTAL

FGI-101-1A6

Intervention Type DRUG

anti-TSG101 human monoclonal antibody, single dose

Placebo

Intervention: Drug-Placebo

Group Type PLACEBO_COMPARATOR

FGI-101-1A6

Intervention Type DRUG

anti-TSG101 human monoclonal antibody, single dose

Interventions

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FGI-101-1A6

anti-TSG101 human monoclonal antibody, single dose

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers ages 18-45
* Normal laboratory (blood tests) results

Exclusion Criteria

* Prior immunization with live-attenuated vaccines
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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United States Department of Defense

FED

Sponsor Role collaborator

Functional Genetics Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Functional Genetics

Locations

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SNBL Clinical Pharmacology Center

Baltimore, Maryland, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Melinda Roberson

Role: CONTACT

410-706-8877

Facility Contacts

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Roberson

Role: primary

Other Identifiers

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W911NF-11-C-0029

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

FGI-101-CP002

Identifier Type: -

Identifier Source: org_study_id

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