HBRN: Immune Regulation and Costimulation in Natural History of Chronic Hepatitis B
NCT ID: NCT01298037
Last Updated: 2026-01-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
201 participants
OBSERVATIONAL
2011-02-01
2026-12-01
Brief Summary
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Detailed Description
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Aim 2: Clinical hepatitis flares during chronic hepatitis B reflect altered balance between immune regulatory and effector responses.
Conditions
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Study Design
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OTHER
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Hgb\<10 or Hct\<30, congestive heart failure or chronic lung disease requiring oxygen, active coronary artery disease with unstable angina, sepsis or renal failure, other significant medical conditions, autoimmune disease or immunosuppression.
18 Years
ALL
Yes
Sponsors
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
University of Pennsylvania
OTHER
Responsible Party
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Kyong-Mi Chang
Professor, Gastroenterology
Principal Investigators
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Kyong-Mi Chang, MD
Role: PRINCIPAL_INVESTIGATOR
University of Pennsylvania
Locations
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California Pacific Medical Center
San Francisco, California, United States
University of California San Francisco Medical Center
San Francisco, California, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
University of Minnesota
Plymouth, Minnesota, United States
Mayo Clinic Rochester
Rochester, Minnesota, United States
University of North Carolina
Chapel Hill, North Carolina, United States
University of Texas Southwestern
Dallas, Texas, United States
Virginia Commonwealth University
Richmond, Virginia, United States
Virginia Mason Medical Center
Seattle, Washington, United States
Harborview Medical Center
Seattle, Washington, United States
University of Toronto
Toronto, Ontario, Canada
Countries
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Related Links
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The Hepatitis B Research Network study web site
Other Identifiers
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DK082864 HBRN Immunology
Identifier Type: -
Identifier Source: org_study_id
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