Evaluation of Neuroprotective Effect of Minocycline

NCT ID: NCT01297816

Last Updated: 2011-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Study Classification

INTERVENTIONAL

Study Start Date

2010-12-31

Study Completion Date

2011-04-30

Brief Summary

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This process appears as a incredible and progressive event that will not stop till reattachment of RPE and neurosensory retina happened .

Process of degeneration begins from first hours of RD (Retinal Detachment) establishment Neuroprotection of photoreceptor following RD is a novel and debatable discussion encountered in recent years .

How to stop this phenomena and neuroprotective agent role in this issue are a new interest of researcher.

In the study the investigators are planning to perform a clinical trial to demonstrate the minocycline neuroprotective effect in a double blind design as this impact has been implicated previously in a animal study

Detailed Description

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Conditions

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Retinal Detachment

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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placebo

100mg-

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

100mg,BD, fo three month

minocyclin

Group Type PLACEBO_COMPARATOR

Minocycline

Intervention Type DRUG

100mg

Interventions

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placebo

100mg,BD, fo three month

Intervention Type DRUG

Minocycline

100mg

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* age over 8 years old
* gender of both sex
* normal liver and renal function
* informed consent received from all patients
* no pregnancy and no lactation
* minimal sun exposure

Exclusion Criteria

* old RD
* diabetic retina
* previous retinal surgery CRF\& liver disfunction RD + PVR \> B Hyper sensitivity to tetracycline History previous MPC or PRP Patients unsuccessful SB (retina is off )
Minimum Eligible Age

8 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shahid Beheshti University of Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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Ophthalmic Research center

Locations

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Labbafinejad medical center

Tehran, Tehran Province, Iran

Site Status RECRUITING

Countries

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Iran

Facility Contacts

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Mohsen Azarmina, Associate Professor

Role: primary

00982122585952

Other Identifiers

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89122

Identifier Type: -

Identifier Source: org_study_id

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