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Imaging of Cognition, Learning, and Memory in Aging

NCT ID: NCT01297114

Last Updated: 2017-11-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

294 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-03-31

Study Completion Date

2017-10-01

Brief Summary

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This investigation is designed to study how the brain functions when it is performing explicit memory tasks, and furthermore how the brain systems supporting performance on these tests change as a function of aging. Implicit memory tasks may be distinguished from explicit memory tests in that explicit memory characterizes the directed or intentional recollection of previously learned information or events. In contrast, implicit (or nonconscious) memory is expressed in the facilitation of performance on some task or judgment on a stimulus owing to a prior presentation of that stimulus, without any necessary conscious awareness of the prior presentation. The investigators propose to use functional Magnetic resonance Imaging (fMRI) to measure brain activity during the performance of carefully designed explicit memory tasks. Comparison of brain activity during the different test conditions will provide information about the brain areas that are involved in mediating specific aspects of performance. Both older and younger individuals will be tested in order to understand age related changes in the brain activity. In order to examine the interactions between participants' differential levels of amyloid burden and their performance on cognitive tasks and fMRI neural activation, the investigators also propose PET imaging of older participants.

Detailed Description

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The basic approach to measuring the brain activity associated with a given cognitive process (or processes) is as follows: It is known that increases in brain neuronal activity are associated with local increases in energy metabolism. Under normal circumstances, increases in brain metabolism lead to local changes in blood oxygenation in venules and larger veins. This change in blood oxygenation can be detected imaging methods which are sensitive to the differences in magnetic state between oxygenated and deoxygenated hemoglobin.

The ultimate benefit of this research is to better understand how changes in both performance and the brain organization underlying that performance are affected by aging.

Conditions

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Alzheimer's Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Participants aged 60-70

Participants age 60-70 will receive Florbetaben PET tracer to identify presence of amyloid burden.

Florbetaben

Intervention Type DRUG

This is a purely observational study. Results of the Florbetaben PET scan will be correlated with other observations.

Participants aged 20-30

Younger participants will not undergo PET scanning that will be studied with other methods.

No interventions assigned to this group

Interventions

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Florbetaben

This is a purely observational study. Results of the Florbetaben PET scan will be correlated with other observations.

Intervention Type DRUG

Other Intervention Names

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F-18 BAY

Eligibility Criteria

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Inclusion Criteria

* Aged 20-30 or 60-70
* Residing near Columbia University Medical Center
* Must be willing and able to participate

Exclusion Criteria

* Have a contraindication to PET (e.g, metallic implants, pacemaker, claustrophobia, or cannot lie flat for one hour)
* Pregnancy
* Lactating Women
* Current, past, or anticipated exposure to radiation
* Significant active physical illness
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Aging (NIA)

NIH

Sponsor Role collaborator

Yaakov Stern

OTHER

Sponsor Role lead

Responsible Party

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Yaakov Stern

Professor of Neuropsychology

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Yaakov Stern, PhD

Role: PRINCIPAL_INVESTIGATOR

Columbia University

Locations

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Columbia University Medical Center

New York, New York, United States

Site Status

Countries

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United States

References

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Oh H, Steffener J, Razlighi QR, Habeck C, Stern Y. beta-Amyloid Deposition Is Associated with Decreased Right Prefrontal Activation during Task Switching among Cognitively Normal Elderly. J Neurosci. 2016 Feb 10;36(6):1962-70. doi: 10.1523/JNEUROSCI.3266-15.2016.

Reference Type BACKGROUND
PMID: 26865619 (View on PubMed)

Oh H, Steffener J, Razlighi QR, Habeck C, Liu D, Gazes Y, Janicki S, Stern Y. Abeta-related hyperactivation in frontoparietal control regions in cognitively normal elderly. Neurobiol Aging. 2015 Dec;36(12):3247-3254. doi: 10.1016/j.neurobiolaging.2015.08.016. Epub 2015 Aug 24.

Reference Type BACKGROUND
PMID: 26382734 (View on PubMed)

Other Identifiers

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R01AG026158

Identifier Type: NIH

Identifier Source: secondary_id

View Link

AAAB0596

Identifier Type: -

Identifier Source: org_study_id