Trial Outcomes & Findings for Effect of Remote Ischaemic Preconditioning on Renal Function in Patients Undergoing Living Donor Kidney Transplantation (NCT NCT01289548)
NCT ID: NCT01289548
Last Updated: 2013-09-10
Results Overview
Plasma creatinine concentration before surgery, 1hour, 4hours, 24hours, 48hours and 72hours after the artery unclamping
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
120 participants
Primary outcome timeframe
within the first 3days after the operation
Results posted on
2013-09-10
Participant Flow
Patients scheduled for living donor renal transplantation in the Department of Transplantation, Tongji Hospital, Huazhong University of Science and Technology were recruited in the project from May 2010 to November 2011.
68 pairs of patients were enrolled during the recruitment period. among them, 5 recipients had the history of renal transplantation before; 2 recipients had concomitant diabetes mellitus; and another one recipient had severe varicose vein in his lower limb. The left 60 pairs of donors and recipients (120 in total) were finally assigned to groups.
Participant milestones
| Measure |
Control
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min
|
Donor RIPC
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient PIPC
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Overall Study
STARTED
|
40
|
40
|
40
|
|
Overall Study
Donors
|
20
|
20
|
20
|
|
Overall Study
Recipients
|
20
|
20
|
20
|
|
Overall Study
COMPLETED
|
40
|
40
|
40
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Effect of Remote Ischaemic Preconditioning on Renal Function in Patients Undergoing Living Donor Kidney Transplantation
Baseline characteristics by cohort
| Measure |
Control
n=20 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=20 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=20 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Total
n=60 Participants
Total of all reporting groups
|
|---|---|---|---|---|
|
Age Continuous
|
46.9 years
STANDARD_DEVIATION 6.4 • n=5 Participants
|
47.4 years
STANDARD_DEVIATION 10.0 • n=7 Participants
|
48.7 years
STANDARD_DEVIATION 5.2 • n=5 Participants
|
47.6 years
STANDARD_DEVIATION 7.4 • n=4 Participants
|
|
Sex: Female, Male
Female
|
12 Participants
n=5 Participants
|
14 Participants
n=7 Participants
|
10 Participants
n=5 Participants
|
36 Participants
n=4 Participants
|
|
Sex: Female, Male
Male
|
8 Participants
n=5 Participants
|
6 Participants
n=7 Participants
|
10 Participants
n=5 Participants
|
24 Participants
n=4 Participants
|
|
Region of Enrollment
China
|
20 donors/recipients pairs
n=5 Participants
|
20 donors/recipients pairs
n=7 Participants
|
20 donors/recipients pairs
n=5 Participants
|
60 donors/recipients pairs
n=4 Participants
|
|
Body mass index (BMI)
|
22.19 kg/m^2
STANDARD_DEVIATION 3.51 • n=5 Participants
|
22.19 kg/m^2
STANDARD_DEVIATION 2.43 • n=7 Participants
|
23.45 kg/m^2
STANDARD_DEVIATION 2.61 • n=5 Participants
|
22.61 kg/m^2
STANDARD_DEVIATION 2.90 • n=4 Participants
|
|
Cold ischemic time
|
175.65 minutes
STANDARD_DEVIATION 36.35 • n=5 Participants
|
166.25 minutes
STANDARD_DEVIATION 19.22 • n=7 Participants
|
177.25 minutes
STANDARD_DEVIATION 27.59 • n=5 Participants
|
173.05 minutes
STANDARD_DEVIATION 28.52 • n=4 Participants
|
|
Relationship
parents
|
12 donors/recipients pairs
n=5 Participants
|
16 donors/recipients pairs
n=7 Participants
|
14 donors/recipients pairs
n=5 Participants
|
42 donors/recipients pairs
n=4 Participants
|
|
Relationship
siblings
|
6 donors/recipients pairs
n=5 Participants
|
2 donors/recipients pairs
n=7 Participants
|
5 donors/recipients pairs
n=5 Participants
|
13 donors/recipients pairs
n=4 Participants
|
|
Relationship
spouses
|
2 donors/recipients pairs
n=5 Participants
|
2 donors/recipients pairs
n=7 Participants
|
1 donors/recipients pairs
n=5 Participants
|
5 donors/recipients pairs
n=4 Participants
|
PRIMARY outcome
Timeframe: within the first 3days after the operationPopulation: All patients completed the trial and no dropout occured.
Plasma creatinine concentration before surgery, 1hour, 4hours, 24hours, 48hours and 72hours after the artery unclamping
Outcome measures
| Measure |
Control
n=20 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=20 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=20 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Plasma Creatine Concentration of the Recipients
before operation
|
849.5 μmol/l
Inter-Quartile Range 122.34 • Interval 711.5 to 936.0
|
878.5 μmol/l
Inter-Quartile Range 258.41 • Interval 717.8 to 1143.5
|
771.0 μmol/l
Inter-Quartile Range 205.40 • Interval 559.5 to 860.3
|
|
Plasma Creatine Concentration of the Recipients
1hour after the artery unclamping
|
776.5 μmol/l
Inter-Quartile Range 102.74 • Interval 686.5 to 867.5
|
797.5 μmol/l
Inter-Quartile Range 231.99 • Interval 645.0 to 1060.0
|
725.5 μmol/l
Inter-Quartile Range 182.56 • Interval 636.8 to 814.5
|
|
Plasma Creatine Concentration of the Recipients
4hours after the artery unclamping
|
651.5 μmol/l
Inter-Quartile Range 118.27 • Interval 555.5 to 710.5
|
639.0 μmol/l
Inter-Quartile Range 226.72 • Interval 494.8 to 883.3
|
600.5 μmol/l
Inter-Quartile Range 213.39 • Interval 420.3 to 728.5
|
|
Plasma Creatine Concentration of the Recipients
24hours after the artery unclamping
|
222.5 μmol/l
Inter-Quartile Range 102.44 • Interval 183.5 to 329.5
|
240.5 μmol/l
Inter-Quartile Range 92.51 • Interval 166.5 to 353.0
|
253.5 μmol/l
Inter-Quartile Range 121.40 • Interval 163.0 to 382.0
|
|
Plasma Creatine Concentration of the Recipients
48hours after the artery unclamping
|
150.0 μmol/l
Inter-Quartile Range 80.35 • Interval 129.8 to 241.8
|
193.5 μmol/l
Inter-Quartile Range 74.69 • Interval 121.8 to 252.8
|
176.5 μmol/l
Inter-Quartile Range 96.18 • Interval 112.8 to 282.8
|
|
Plasma Creatine Concentration of the Recipients
72hours after the artery unclamping
|
120 μmol/l
Inter-Quartile Range 48.25 • Interval 110.5 to 167.0
|
153.0 μmol/l
Inter-Quartile Range 73.61 • Interval 98.8 to 216.3
|
126.5 μmol/l
Inter-Quartile Range 71.78 • Interval 98.5 to 225.3
|
PRIMARY outcome
Timeframe: within the first 3days after the operationPopulation: All patients completed the trial and no dropout occured.
Accumulated urinary output 1hour, 4hours and 24hours after the artery unclamping and the urinary output on the 2nd and 3rd day after the operation
Outcome measures
| Measure |
Control
n=20 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=20 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=20 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Urinary Output of the Recipients Postoperatively
within 1hour after the artery unclamping
|
175 ml
Inter-Quartile Range 265.1 • Interval 63.0 to 400.0
|
300 ml
Inter-Quartile Range 239.6 • Interval 100.0 to 575.0
|
100 ml
Inter-Quartile Range 220.4 • Interval 63.0 to 300.0
|
|
Urinary Output of the Recipients Postoperatively
within 4hours after the artery unclamping
|
1875 ml
Inter-Quartile Range 1502.7 • Interval 1030.0 to 3338.0
|
2650 ml
Inter-Quartile Range 1271.9 • Interval 1613.0 to 3600.0
|
1850 ml
Inter-Quartile Range 999.8 • Interval 1138.0 to 2775.0
|
|
Urinary Output of the Recipients Postoperatively
within 24hours after the artery unclamping
|
8775 ml
Inter-Quartile Range 5289.8 • Interval 5030.0 to 12588.0
|
10025 ml
Inter-Quartile Range 5151.0 • Interval 4338.0 to 13850.0
|
6375 ml
Inter-Quartile Range 3497.0 • Interval 4413.0 to 8888.0
|
|
Urinary Output of the Recipients Postoperatively
on the 2nd day after the operation
|
5355 ml
Inter-Quartile Range 2051.7 • Interval 3838.0 to 7000.0
|
5200 ml
Inter-Quartile Range 3846.3 • Interval 2900.0 to 6778.0
|
4020 ml
Inter-Quartile Range 1984.5 • Interval 3438.0 to 5625.0
|
|
Urinary Output of the Recipients Postoperatively
on the 3rd day after the operation
|
4600 ml
Inter-Quartile Range 1215.9 • Interval 3050.0 to 5348.0
|
3765 ml
Inter-Quartile Range 2166.7 • Interval 2613.0 to 5138.0
|
3650 ml
Inter-Quartile Range 1451.5 • Interval 2913.0 to 5260.0
|
PRIMARY outcome
Timeframe: within the first 24hours after the operationPopulation: All patients completed the trial and no dropout occured.
Plasma concentration of neutrophil gelatinase-associated lipocalin (NGAL) before the operation and 24hours after the artery unclamping
Outcome measures
| Measure |
Control
n=20 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=20 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=20 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Plasma Concentration of NGAL in the Recipients
before operation
|
1478.7 ng/ml
Inter-Quartile Range 617.65 • Interval 976.1 to 1794.3
|
1269.1 ng/ml
Inter-Quartile Range 603.10 • Interval 1077.9 to 1839.2
|
1377.9 ng/ml
Inter-Quartile Range 677.98 • Interval 940.6 to 1838.5
|
|
Plasma Concentration of NGAL in the Recipients
24hours after the artery unclamping
|
317.8 ng/ml
Inter-Quartile Range 210.41 • Interval 225.0 to 440.1
|
370.1 ng/ml
Inter-Quartile Range 212.51 • Interval 113.8 to 523.5
|
256.2 ng/ml
Inter-Quartile Range 309.04 • Interval 128.8 to 571.5
|
SECONDARY outcome
Timeframe: before dischargePopulation: All the patients completed the study and no dropout occured.
biopsy-confirmed, clinically symptomatic
Outcome measures
| Measure |
Control
n=20 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=20 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=20 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Acute Rejection of Transplanted Kidney
|
0 participants
|
0 participants
|
0 participants
|
SECONDARY outcome
Timeframe: before dischargePopulation: All the patients completed the study and no dropout occured.
Delayed Graft Function according to the clinical symptoms
Outcome measures
| Measure |
Control
n=20 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=20 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=20 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Delayed Graft Function
|
1 participants
|
2 participants
|
2 participants
|
SECONDARY outcome
Timeframe: before dischargePopulation: All the patients completed the study and no dropout occured.
time from the day of operation to the day of discharge for the recipients
Outcome measures
| Measure |
Control
n=20 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=20 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=20 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Length of Postoperative Hospital Stay
|
17 day
Inter-Quartile Range 4.8 • Interval 15.0 to 21.8
|
15 day
Inter-Quartile Range 3.7 • Interval 14.0 to 16.8
|
14.5 day
Inter-Quartile Range 8.2 • Interval 13.0 to 24.0
|
SECONDARY outcome
Timeframe: from the admission to the discharge of the patientsPopulation: All the patients completed the study and no dropout occured.
Total costs from the admission to the discharge of the recipients
Outcome measures
| Measure |
Control
n=20 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=20 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=20 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Total Costs During the Hospitalization
|
82499 RMB yuan
Inter-Quartile Range 23625.18 • Interval 77320.0 to 127140.0
|
83574 RMB yuan
Inter-Quartile Range 22164.70 • Interval 73912.0 to 125100.0
|
82298 RMB yuan
Inter-Quartile Range 24113.99 • Interval 72201.0 to 136900.0
|
SECONDARY outcome
Timeframe: before operationPopulation: Urine could not be obtained from the other 46 patients because of anuria.
Urine concentration of N-acetyl-D-glucosaminidase (NAG) before the operation
Outcome measures
| Measure |
Control
n=8 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=1 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=5 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Urine Concentration of NAG Preoperatively in Recipients
|
20.79 U/L
Standard Deviation 13.68
|
15.25 U/L
Standard Deviation 0
|
16.09 U/L
Standard Deviation 20.71
|
SECONDARY outcome
Timeframe: within the first 24hours after the artery unclampingPopulation: All patients completed the trial and no dropout occured.
Urine concentration of N-acetyl-D-glucosaminidase (NAG) 1hour, 4hours and 24hours after the artery unclamping in the recipients
Outcome measures
| Measure |
Control
n=20 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=20 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=20 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Urine Concentration of NAG Postoperatively in Recipients
1hour after the artery unclamping
|
16.58 U/L
Inter-Quartile Range 26.94 • Interval 4.67 to 54.75
|
18.54 U/L
Inter-Quartile Range 29.58 • Interval 2.99 to 24.02
|
17.06 U/L
Inter-Quartile Range 31.30 • Interval 2.25 to 36.54
|
|
Urine Concentration of NAG Postoperatively in Recipients
4hours after the artery unclamping
|
3.74 U/L
Inter-Quartile Range 3.27 • Interval 1.3 to 7.12
|
4.45 U/L
Inter-Quartile Range 10.37 • Interval 1.99 to 10.38
|
6.46 U/L
Inter-Quartile Range 6.92 • Interval 1.99 to 13.1
|
|
Urine Concentration of NAG Postoperatively in Recipients
24hours after the artery unclamping
|
3.73 U/L
Inter-Quartile Range 7.36 • Interval 1.66 to 6.72
|
2.65 U/L
Inter-Quartile Range 3.01 • Interval 1.99 to 5.5
|
4.13 U/L
Inter-Quartile Range 2.87 • Interval 1.69 to 5.8
|
SECONDARY outcome
Timeframe: before the operationPopulation: No urine could be obtained from the other 46 patients because of anuria.
Urine concentration of retinol binding protein (RBP) before the operation in the recipients
Outcome measures
| Measure |
Control
n=8 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=1 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=5 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Urine Concentration of RBP Preoperatively in the Recipients
|
2.222 mg/L
Standard Deviation 0.315
|
2.168 mg/L
Standard Deviation 0
|
1.964 mg/L
Standard Deviation 0.465
|
SECONDARY outcome
Timeframe: within the first 24hours after the artery unclampingPopulation: All patients completed the trial and no dropout occured.
Urine concentration of retinol binding protein (RBP) 1hour, 4hours and 24hours after the artery unclamping in the recipients
Outcome measures
| Measure |
Control
n=20 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=20 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=20 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Urine Concentration of RBP Postoperatively in the Recipients
1hour after the artery unclamping
|
2.18 mg/L
Inter-Quartile Range 0.44 • Interval 1.79 to 2.35
|
1.93 mg/L
Inter-Quartile Range 0.42 • Interval 1.69 to 2.45
|
2.05 mg/L
Inter-Quartile Range 0.44 • Interval 1.92 to 2.3
|
|
Urine Concentration of RBP Postoperatively in the Recipients
4hours after the artery unclamping
|
2.23 mg/L
Inter-Quartile Range 0.28 • Interval 1.82 to 2.35
|
1.94 mg/L
Inter-Quartile Range 0.48 • Interval 1.66 to 2.35
|
2.27 mg/L
Inter-Quartile Range 0.56 • Interval 1.92 to 2.55
|
|
Urine Concentration of RBP Postoperatively in the Recipients
24hours after the artery unclamping
|
2.05 mg/L
Inter-Quartile Range 0.48 • Interval 1.69 to 2.35
|
1.91 mg/L
Inter-Quartile Range 0.43 • Interval 1.79 to 2.17
|
1.94 mg/L
Inter-Quartile Range 0.50 • Interval 1.79 to 2.41
|
SECONDARY outcome
Timeframe: within 24hours after the operationPopulation: All patients completed the trial and no dropout occured.
Plasma concentration of superoxide dismutase (SOD) before the operation, 1hour, 4hours and 24hours after the artery unclamping in the recipients
Outcome measures
| Measure |
Control
n=20 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=20 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=20 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Plasma Concentration of SOD in the Recipients
before operation
|
105.04 U/ml
Inter-Quartile Range 27.08 • Interval 77.79 to 121.9
|
96.77 U/ml
Inter-Quartile Range 29.79 • Interval 82.91 to 136.46
|
113.51 U/ml
Inter-Quartile Range 23.86 • Interval 93.79 to 136.71
|
|
Plasma Concentration of SOD in the Recipients
1hour after the artery unclamping
|
88.86 U/ml
Inter-Quartile Range 21.41 • Interval 79.19 to 110.06
|
94.90 U/ml
Inter-Quartile Range 28.96 • Interval 78.03 to 128.18
|
112.25 U/ml
Inter-Quartile Range 23.92 • Interval 91.63 to 115.24
|
|
Plasma Concentration of SOD in the Recipients
4hours after the artery unclamping
|
76.47 U/ml
Inter-Quartile Range 28.81 • Interval 47.86 to 96.41
|
90.67 U/ml
Inter-Quartile Range 32.49 • Interval 69.43 to 115.08
|
89.36 U/ml
Inter-Quartile Range 22.47 • Interval 80.01 to 102.75
|
|
Plasma Concentration of SOD in the Recipients
24hours after the artery unclamping
|
41.47 U/ml
Inter-Quartile Range 33.83 • Interval 33.77 to 95.03
|
64.13 U/ml
Inter-Quartile Range 34.99 • Interval 32.92 to 83.01
|
68.04 U/ml
Inter-Quartile Range 29.27 • Interval 42.4 to 80.09
|
SECONDARY outcome
Timeframe: within the first 24hours after the operationPopulation: All patients completed the trial and no dropout occured.
Plasma concentration of malondialdehyde (MDA) before the operation, 1hour, 4hours and 24hours after the artery unclamping in the recipients
Outcome measures
| Measure |
Control
n=20 Participants
patients (both donors and recipients) had a deflated cuff placed on the left lower limb for 30 min.
|
Donor + RIPC
n=20 Participants
Donors receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; recipients only have a deflated blood pressure cuff around their leg for 30 minutes.
|
Recipient +RIPC
n=20 Participants
recipients receive remote ischaemic preconditioning after anaesthesia induction and before surgery started; donors only have a deflated blood pressure cuff around their leg for 30 minutes.
|
|---|---|---|---|
|
Plasma Concentration of MDA in the Recipients
1hour after the artery unclamping
|
3.58 nmol/ml
Inter-Quartile Range 0.80 • Interval 3.2 to 4.3
|
4.15 nmol/ml
Inter-Quartile Range 0.59 • Interval 3.51 to 4.63
|
3.91 nmol/ml
Inter-Quartile Range 0.77 • Interval 3.56 to 4.29
|
|
Plasma Concentration of MDA in the Recipients
4hours after the artery unclamping
|
3.60 nmol/ml
Inter-Quartile Range 0.80 • Interval 2.9 to 4.21
|
3.46 nmol/ml
Inter-Quartile Range 0.92 • Interval 3.12 to 4.36
|
3.54 nmol/ml
Inter-Quartile Range 0.84 • Interval 3.25 to 4.22
|
|
Plasma Concentration of MDA in the Recipients
24hours after the artery unclamping
|
2.97 nmol/ml
Inter-Quartile Range 0.88 • Interval 2.65 to 3.62
|
3.57 nmol/ml
Inter-Quartile Range 0.72 • Interval 2.86 to 3.93
|
3.36 nmol/ml
Inter-Quartile Range 0.83 • Interval 2.87 to 3.86
|
|
Plasma Concentration of MDA in the Recipients
before operation
|
2.96 nmol/ml
Inter-Quartile Range 0.72 • Interval 2.52 to 3.75
|
3.34 nmol/ml
Inter-Quartile Range 0.70 • Interval 2.82 to 3.82
|
3.14 nmol/ml
Inter-Quartile Range 0.65 • Interval 2.91 to 3.66
|
Adverse Events
Control
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Donor + RIPC
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Recipient +RIPC
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Hua zheng
Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Phone: 00862783663173
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place