High Dose BAYA1040_Nifedipine: a Dose-comparative Study

NCT ID: NCT01287260

Last Updated: 2014-01-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

352 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2011-08-31

Brief Summary

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This is a clinical study evaluating the superiority in efficacy and assess safety and tolerability of BAYA1040\_Nifedipine 80 mg/day (40 mg twice daily) compared with BAYA1040\_Nifedipine 40 mg/day (40 mg once daily) in patients with essential hypertension who are not at target blood pressure by BAYA1040\_Nifedipine 40 mg once daily treatment.

Detailed Description

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Conditions

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Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Arm1

Group Type EXPERIMENTAL

Nifedipine (Adalat, BAYA1040)

Intervention Type DRUG

BAYA1040\_Nifedipine 40mg twice daily (BID)

Arm 2

Group Type ACTIVE_COMPARATOR

Nifedipine (Adalat, BAYA1040)

Intervention Type DRUG

BAYA1040\_Nifedipine 40mg once daily (OD)

Interventions

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Nifedipine (Adalat, BAYA1040)

BAYA1040\_Nifedipine 40mg twice daily (BID)

Intervention Type DRUG

Nifedipine (Adalat, BAYA1040)

BAYA1040\_Nifedipine 40mg once daily (OD)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 20 years or older
* Japanese male or female
* Outpatient with essential hypertension
* Patients whose sitting diastolic blood pressure (DBP) is 90 mmHg or more despite more than 4 weeks of treatment with antihypertensive drug

Exclusion Criteria

* Sitting diastolic blood pressure (DBP) is 110 mmHg or more or sitting systolic blood pressure (SBP) is 180 mmHg or more
* Patients with secondary hypertension or hypertensive emergency
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bayer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bayer Study Director

Role: STUDY_DIRECTOR

Bayer

Locations

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Hirosaki, Aomori, Japan

Site Status

Kamagaya, Chiba, Japan

Site Status

Asahikawa, Hokkaido, Japan

Site Status

Asahikawa, Hokkaido, Japan

Site Status

Sapporo, Hokkaido, Japan

Site Status

Sapporo, Hokkaido, Japan

Site Status

Sapporo, Hokkaido, Japan

Site Status

Sapporo, Hokkaido, Japan

Site Status

Sapporo, Hokkaido, Japan

Site Status

Sapporo, Hokkaido, Japan

Site Status

Sapporo, Hokkaido, Japan

Site Status

Sapporo, Hokkaido, Japan

Site Status

Kawasaki, Kanagawa, Japan

Site Status

Daitō, Osaka, Japan

Site Status

Kishiwada, Osaka, Japan

Site Status

Yao, Osaka, Japan

Site Status

Tokorozawa, Saitama, Japan

Site Status

Shizuoka, Shizuoka, Japan

Site Status

Hachiōji, Tokyo, Japan

Site Status

Meguro City, Tokyo, Japan

Site Status

Minato, Tokyo, Japan

Site Status

Minato, Tokyo, Japan

Site Status

Countries

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Japan

References

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Shimamoto K, Hasebe N, Ito S, Kario K, Kimura K, Dohi Y, Kawano Y, Rakugi H, Horiuchi M, Imaizumi T, Ohya Y. Nifedipine controlled-release 40 mg b.i.d. in Japanese patients with essential hypertension who responded insufficiently to nifedipine controlled-release 40 mg q.d.: a phase III, randomized, double-blind and parallel-group study. Hypertens Res. 2014 Jan;37(1):69-75. doi: 10.1038/hr.2013.80. Epub 2013 Aug 15.

Reference Type DERIVED
PMID: 23945965 (View on PubMed)

Other Identifiers

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13176

Identifier Type: -

Identifier Source: org_study_id

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