Preoperative Biochemical Predictors of Outcome in Patients With Hip Fracture

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

999 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-31

Brief Summary

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The objective of the study is to identify biochemical predictors of morbidity and mortality in patients suffering from hip fracture. For this purpose blood samples are collected prehospitally or in the emergency department in patients with a suspected hip fracture. During the hospital stay medical history, anesthesiological management recorded. In addition, american society of anesthesiology physiological score (ASA), revised cardiac risk index (RCRI), and POSSUM score is calculated. Morbidity and mortality is recorded " in house", after 30 days, after 4 months and after 1 year. Biochemical predictors of outcome will be evaluated with logistic regression analysis. Biochemical predictors include pro-brain natriuretic peptide, lactate, pro-calcitonin, adrenomedullin, copeptin, cystatin c. The predictive value of the potential markers will be compared to that of ASA, RCRI and POSSUM.

Detailed Description

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Conditions

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Hip Fracture

Keywords

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Predictor outcome biochemical

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients presenting with out of hospital hip fracture at University Hospital Lund Sweden
* Informed consent
* Blood sampling within 3 hrs of first contact with healthcare

Exclusion Criteria

* No consent can be obtained
* Non-operative management
* Followup through the Swedish National Quality for Hip fracture patients not possible
* High energy trauma

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Peter Bentzer, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Skane University Hospital

Locations

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Skane University Hospital, Lund

Lund, Skåne County, Sweden

Site Status

Countries

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Sweden

Other Identifiers

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2010

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

1837