The STAPLE International Post-Market Registry

NCT ID: NCT01276249

Last Updated: 2021-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Total Enrollment

108 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-08-31

Study Completion Date

2015-06-19

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The Aptus Endosystems STAPLE International Post-Market Registry is intended to expand the clinical knowledge base by including 'real world' subjects.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The Aptus Endosystems STAPLE International Post-Market Registry is intended to expand the clinical knowledge base by including 'real world' subjects.

All subjects diagnosed with a qualifying AAA suitable for elective endovascular repair, who meet the inclusion/exclusion criteria for the registry, are eligible for enrollment and should be offered informed consent to participate.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Aortic Aneurysm, Abdominal Aorto Iliac Aneurysm

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Aptus Endosystem EndoStaple Endograft Stent Graft Abdominal Aortic Aneurysm Heli-FX EndoAnchor

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Fortevo Endograft

All subjects diagnosed with a qualifying AAA suitable for elective endovascular repair, who meet the inclusion/exclusion criteria for the registry, are eligible for enrollment if treated with the Fortevo Endograft.

Fortevo Endograft

Intervention Type DEVICE

The Fortevo Endograft, Main Body and Iliac Lumen Delivery System are indicated for the endovascular treatments of patients with infrarenal abdominal aortic aneurysms or aortic-iliac aneurysms having suitable morphology for endovascular repair.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Fortevo Endograft

The Fortevo Endograft, Main Body and Iliac Lumen Delivery System are indicated for the endovascular treatments of patients with infrarenal abdominal aortic aneurysms or aortic-iliac aneurysms having suitable morphology for endovascular repair.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Patient ≥ 18 years old
2. Patient has given written informed consent
3. Patient has a life expectancy \> 1 year
4. Patient is willing to comply with follow-up evaluations
5. Patient's AAA meets at least one of the following criteria:

* ≥ 4.5cm in diameter
* Increased in size by 0.5cm in last 6 months
* Maximum diameter exceeds 1.5 times the transverse dimension of an adjacent normal aortic segment
* Saccular aneurysm larger than 3cm in maximal diameter
6. Patient has a proximal aortic neck diameter measured inner wall to inner wall between 19mm and 29mm
7. Patient has a proximal aortic neck length of at least 12mm
8. Patient has a patent iliac or femoral artery that allows endovascular access to the aneurysmal site with 16Fr (5.3mm) or 18Fr (6.0mm) delivery system.
9. Patient has bilateral iliac artery distal fixation site ≥ 10mm in length with an internal diameter between 9mm and 20mm

Exclusion Criteria

1. Patient is participating in a concurrent clinical study which may confound STAPLE-International Registry results
2. Patient has a symptomatic AAA
3. Patient's AAA has a proximal aortic neck angle that is \> 60 degrees between the infrarenal neck and the long axis of the aneurysm
4. Patient has irregularly-shaped plaque that would inhibit sealing stent apposition
5. Patient has aortic mural pathology that is ≥ 2mm in thickness over ≥ 50% of the circumference of the proximal fixation site
6. Patient has an active, or known history of, bleeding diathesis or hypercoagulable condition
7. Patient has a contraindication to any materials to which he or she will be exposed during the EVAR procedure (i.e., Fortevo Endograft or Heli-FX EndoAnchor System materials, contrast agents)
8. Patient has a genetic connective tissue disorder (e.g., Marfan's or Ehlers-Danloe Syndromes)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Medtronic Cardiovascular

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Jean-Paul de Vries, MD

Role: PRINCIPAL_INVESTIGATOR

St Antonius Hospital - Nieuwegein, Netherlands

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Sherbrooke University Hospital Centre

Sherbrooke, Quebec, Canada

Site Status

German Heart Center

Berlin, , Germany

Site Status

Cardiovascular Center Frankfurt

Frankfurt, , Germany

Site Status

St. Bonifatious Hospital

Lingen, , Germany

Site Status

Hellenic Airforce Hospital

Athens, , Greece

Site Status

University of Siena

Siena, , Italy

Site Status

St Antonious Hospital

Nieuwegein, , Netherlands

Site Status

Thorax Institute Hospital Clinic

Barcelona, , Spain

Site Status

University of Navarra

Pamplona, , Spain

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Austria Turkey (Türkiye) United Kingdom Canada Germany Greece Italy Netherlands Spain

References

Explore related publications, articles, or registry entries linked to this study.

Deaton DH. Future technologies to address the failed endoprosthesis. Semin Vasc Surg. 2009 Jun;22(2):111-8. doi: 10.1053/j.semvascsurg.2009.04.010.

Reference Type BACKGROUND
PMID: 19573751 (View on PubMed)

Deaton DH, Mehta M, Kasirajan K, Chaikof E, Farber M, Glickman MH, Neville RF, Fairman RM. The phase I multicenter trial (STAPLE-1) of the Aptus endovascular repair system: results at 6 months and 1 year. J Vasc Surg. 2009 Apr;49(4):851-7; discussion 857-8. doi: 10.1016/j.jvs.2008.10.064.

Reference Type RESULT
PMID: 19341879 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

CD03335-01

Identifier Type: -

Identifier Source: org_study_id