Trial Outcomes & Findings for Ultrasound-image Guided Versus Doppler Guided Versus Palpation Technique for Arterial Cannulation in Adults (NCT NCT01276171)

NCT ID: NCT01276171

Last Updated: 2017-06-26

Results Overview

The primary objective of this study is to compare the first attempt success rate for radial artery cannulation between the palpation, Doppler and U/S guided technique when applied by anesthesia trainees. Secondary outcomes include: success rate within 5 minutes, time to successful cannulation compared with three different techniques.

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 749 participants
• Primary outcome timeframe: 5 minutes
• Results posted on: 2017-06-26

Participant Flow

Participant milestones

Measure	Ultrasound Participants will place arterial line using ultrasound technique Ultrasound: Participants will place arterial line using ultrasound technique	Doppler Participants will place arterial line using doppler technique Doppler: Participants will place arterial line using doppler technique	Palpation Participants will place arterial line using palpation technique Palpation: Participants will place arterial line using Palpation technique
Overall Study STARTED	249	244	256
Overall Study COMPLETED	249	244	256
Overall Study NOT COMPLETED	0	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Ultrasound-image Guided Versus Doppler Guided Versus Palpation Technique for Arterial Cannulation in Adults

Baseline characteristics by cohort

Measure	Ultrasound n=249 Participants Participants will place arterial line using ultrasound technique Ultrasound: Participants will place arterial line using ultrasound technique	Doppler n=244 Participants Participants will place arterial line using doppler technique Doppler: Participants will place arterial line using doppler technique	Palpation n=256 Participants Participants will place arterial line using palpation technique Palpation: Participants will place arterial line using Palpation technique	Total n=749 Participants Total of all reporting groups
Age, Categorical <=18 years	0 Participants n=93 Participants	0 Participants n=4 Participants	0 Participants n=27 Participants	0 Participants n=483 Participants
Age, Categorical Between 18 and 65 years	148 Participants n=93 Participants	144 Participants n=4 Participants	157 Participants n=27 Participants	449 Participants n=483 Participants
Age, Categorical >=65 years	101 Participants n=93 Participants	100 Participants n=4 Participants	99 Participants n=27 Participants	300 Participants n=483 Participants
Age, Continuous	60 years n=93 Participants	61 years n=4 Participants	59 years n=27 Participants	60 years n=483 Participants
Sex: Female, Male Female	106 Participants n=93 Participants	107 Participants n=4 Participants	106 Participants n=27 Participants	319 Participants n=483 Participants
Sex: Female, Male Male	143 Participants n=93 Participants	137 Participants n=4 Participants	150 Participants n=27 Participants	430 Participants n=483 Participants
Region of Enrollment United States	249 participants n=93 Participants	244 participants n=4 Participants	256 participants n=27 Participants	749 participants n=483 Participants

PRIMARY outcome

Timeframe: 5 minutes

The primary objective of this study is to compare the first attempt success rate for radial artery cannulation between the palpation, Doppler and U/S guided technique when applied by anesthesia trainees. Secondary outcomes include: success rate within 5 minutes, time to successful cannulation compared with three different techniques.

Outcome measures

Measure	Ultrasound n=249 Participants Participants will place arterial line using ultrasound technique Ultrasound: Participants will place arterial line using ultrasound technique	Doppler n=244 Participants Participants will place arterial line using doppler technique Doppler: Participants will place arterial line using doppler technique	Palpation n=256 Participants Participants will place arterial line using palpation technique Palpation: Participants will place arterial line using Palpation technique
First Attempt Success Rate With 3 Different Technique	132 participants	101 participants	96 participants

SECONDARY outcome

Timeframe: 5 minutes

Outcome measures

Measure	Ultrasound n=249 Participants Participants will place arterial line using ultrasound technique Ultrasound: Participants will place arterial line using ultrasound technique	Doppler n=244 Participants Participants will place arterial line using doppler technique Doppler: Participants will place arterial line using doppler technique	Palpation n=256 Participants Participants will place arterial line using palpation technique Palpation: Participants will place arterial line using Palpation technique
Time to Successful Cannulation	32 min Interval 19.0 to 51.0	118 min Interval 69.0 to 198.0	91 min Interval 60.0 to 153.0

SECONDARY outcome

Timeframe: 5 min

Population: chi-squre test

Outcome measures

Measure	Ultrasound n=249 Participants Participants will place arterial line using ultrasound technique Ultrasound: Participants will place arterial line using ultrasound technique	Doppler n=244 Participants Participants will place arterial line using doppler technique Doppler: Participants will place arterial line using doppler technique	Palpation n=256 Participants Participants will place arterial line using palpation technique Palpation: Participants will place arterial line using Palpation technique
Total Success Rate	170 Participants	147 Participants	160 Participants

Adverse Events

Ultrasound

Serious events: 0 serious events

Other events: 27 other events

Deaths: 0 deaths

Doppler

Serious events: 0 serious events

Other events: 22 other events

Deaths: 0 deaths

Palpation

Serious events: 0 serious events

Other events: 29 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Measure	Ultrasound n=249 participants at risk Participants will place arterial line using ultrasound technique Ultrasound: Participants will place arterial line using ultrasound technique	Doppler n=244 participants at risk Participants will place arterial line using doppler technique Doppler: Participants will place arterial line using doppler technique	Palpation n=256 participants at risk Participants will place arterial line using palpation technique Palpation: Participants will place arterial line using Palpation technique
Blood and lymphatic system disorders Hematoma	10.8% 27/249 • Number of events 27 • 3 days	9.0% 22/244 • Number of events 22 • 3 days	11.3% 29/256 • Number of events 29 • 3 days

Additional Information

Dr. Kenichi Ueda

University of Iowa Hospitals and Clinics

Phone: 319-356-2633

Email: kenichi-ueda@uiowa.edu

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place