New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function

NCT ID: NCT01275963

Last Updated: 2016-11-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-31

Study Completion Date

2016-10-31

Brief Summary

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Assessment of left ventricular systolic function is the most frequent indication for routine echocardiography. Qualitative eyeball method and biplane modified Simpson's rule, both measuring radial ventricular function, are the currently recommended methods to meet this challenge. Due to the complexity of the myocardial architecture, global left ventricular function also has longitudinal and torsional components.

The aim of this study is to evaluate new echocardiographic parameters for longitudinal left ventricular function. A special focus is set on strain imaging by speckle tracking, which is a relatively new technique. Patients with different cardiac pathologies (e. g. dilated cardiomyopathy, coronary artery disease, diastolic dysfunction) will be included and compared to healthy individuals.

Detailed Description

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Conditions

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Cardiovascular Pathology

Keywords

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Echocardiography Strain imaging Ventricular Dysfunction Cardiomyopathy Longitudinal left ventricular function

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Control

Healthy individuals without structural heart disease

No interventions assigned to this group

CAD

Patients with coronary artery disease

No interventions assigned to this group

DCM

Participants with dilated cardiomyopathy

No interventions assigned to this group

HNCM

Patients with hypertrophic non-obstructive cardiomyopathy

No interventions assigned to this group

HOCM

Patients with hypertrophic obstructive cardiomyopathy

No interventions assigned to this group

RCM

Patients with restrictive cardiomyopathy

No interventions assigned to this group

Amyloidosis

Patients with cardiac manifestation of amyloidosis

No interventions assigned to this group

HFPEF

Patients with heart failure with preserved ejection fraction (diastolic heart failure)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* persons of 18 years and older who receive a transthoracic echocardiography at our department
* written consent

Exclusion Criteria

* permanent pacemaker rhythm
* moderate/severe valvular heart disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Heidelberg University

OTHER

Sponsor Role lead

Responsible Party

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Derliz Mereles

Dr. Derliz Mereles

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Matthias Aurich, M.D.

Role: PRINCIPAL_INVESTIGATOR

Heidelberg University

Derliz Mereles, M.D.

Role: PRINCIPAL_INVESTIGATOR

Heidelberg University

Locations

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University of Heidelberg

Heidelberg, , Germany

Site Status

Countries

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Germany

References

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Aurich M, Keller M, Greiner S, Steen H, Aus dem Siepen F, Riffel J, Katus HA, Buss SJ, Mereles D. Left ventricular mechanics assessed by two-dimensional echocardiography and cardiac magnetic resonance imaging: comparison of high-resolution speckle tracking and feature tracking. Eur Heart J Cardiovasc Imaging. 2016 Dec;17(12):1370-1378. doi: 10.1093/ehjci/jew042. Epub 2016 Mar 24.

Reference Type DERIVED
PMID: 27013249 (View on PubMed)

Other Identifiers

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S-401/2010

Identifier Type: -

Identifier Source: org_study_id