Vitamin D Deficiency in Subjects With Chronic Hepatitis C Compared to Healthy Volunteers
NCT ID: NCT01274013
Last Updated: 2019-01-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
OBSERVATIONAL
2009-10-31
2019-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Study Group
Individuals with chronic Hepatitis C
No interventions assigned to this group
Control Group
Healthy individuals
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of chronic hepatitis C
* Men and women between the ages of 20 and 60
* Has a body mass index (BMI) between 20 and 35
Exclusion Criteria
* Has acute hepatitis C infection
* Has chronic hepatitis B infection
* Had gastric bypass surgery
* Has chronic kidney disease
* Taking a vitamin D supplement (by itself or as part of a multivitamin), a calcium supplement and/or biphosphonates
* Has any significant illness or medical problem that is not under control or being controlled by medication
* History of hepatitis or abnormal liver chemistry tests
* History of intravenous drug use
20 Years
60 Years
ALL
Yes
Sponsors
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Avera McKennan Hospital & University Health Center
OTHER
Responsible Party
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Principal Investigators
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Hesham Elgouhari, MD
Role: PRINCIPAL_INVESTIGATOR
Avera McKennan Hospital & University Health Center
Locations
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Avera Research Institute
Sioux Falls, South Dakota, United States
Countries
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References
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Peterlik M, Cross HS. Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest. 2005 May;35(5):290-304. doi: 10.1111/j.1365-2362.2005.01487.x.
DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. doi: 10.1093/ajcn/80.6.1689S.
Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev. 2005 Aug;26(5):662-87. doi: 10.1210/er.2004-0002. Epub 2005 Mar 29.
Fisher L, Fisher A. Vitamin D and parathyroid hormone in outpatients with noncholestatic chronic liver disease. Clin Gastroenterol Hepatol. 2007 Apr;5(4):513-20. doi: 10.1016/j.cgh.2006.10.015. Epub 2007 Jan 10.
Yano M, Ikeda M, Abe K, Dansako H, Ohkoshi S, Aoyagi Y, Kato N. Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. Antimicrob Agents Chemother. 2007 Jun;51(6):2016-27. doi: 10.1128/AAC.01426-06. Epub 2007 Apr 9.
Boucher BJ, John WG, Noonan K. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004 Dec;80(6):1666; author reply 1666-7. doi: 10.1093/ajcn/80.6.1666. No abstract available.
Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int. 2005 Jul;16(7):713-6. doi: 10.1007/s00198-005-1867-7. Epub 2005 Mar 18.
Other Identifiers
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ARI-1280-HEPC
Identifier Type: -
Identifier Source: org_study_id
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