Safety and Efficacy of RX-10100 to Treat Major Depressive Disorder

NCT ID: NCT01273376

Last Updated: 2013-11-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

314 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-12-31

Study Completion Date

2011-10-31

Brief Summary

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The purpose of this study is to determine whether RX-10100 are effective in the treatment of Major Depressive Disorder (MDD).

Detailed Description

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Conditions

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Major Depressive Disorder

Keywords

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MDD Depression Major Depression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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RX-10100 high dose

RX-10100

Study drug is to be given orally, in tablet form, twice daily, for 8 weeks

Group Type EXPERIMENTAL

RX-10100

Intervention Type DRUG

Extended-release tablet, taken twice daily for 8 weeks

RX-10100 low dose

RX-10100

Study drug is to be given orally, in tablet form, twice daily, for 8 weeks

Group Type EXPERIMENTAL

RX-10100

Intervention Type DRUG

Extended-release tablet, taken twice daily for 8 weeks

Placebo

Matching placebo is to be given orally, in tablet form, twice daily, for 8 weeks

Group Type PLACEBO_COMPARATOR

RX-10100

Intervention Type DRUG

Extended-release tablet, taken twice daily for 8 weeks

Interventions

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RX-10100

Extended-release tablet, taken twice daily for 8 weeks

Intervention Type DRUG

Other Intervention Names

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Serdaxin®

Eligibility Criteria

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Inclusion Criteria

• Moderate to severe MDD as determined by the DSM-IV-TR Axis 1 Disorders and by the Montgomery Asberg Depression Rating Scale (MADRS).

Exclusion Criteria

* Women who are pregnant, women who will be breastfeeding during the study, and women with childbearing potential who are not willing to practice a reliable method of birth control
* Depressive episode duration of less than 1 month
* Lifetime history of any psychotic disorders
* Anxiety disorders
* Significant suicidality
* Clinically significant medical conditions
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rexahn Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christine Peterson, Ph.D

Role: STUDY_DIRECTOR

Rexahn Pharmaceuticals, Inc.

Locations

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Rexahn Investigative Site

Cerritos, California, United States

Site Status

Rexahn Investigative Site

Escondido, California, United States

Site Status

Rexahn Investigative Site

Los Angeles, California, United States

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Rexahn Investigative Site

National City, California, United States

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Rexahn Investigative Site

Oceanside, California, United States

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Rexahn Investigative Site

Orange, California, United States

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Rexahn Investigative Site

San Diego, California, United States

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Rexahn Investigative Site

Denver, Colorado, United States

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Rexahn Investigative Site

Brooksville, Florida, United States

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Rexahn Investigative Site

Gainesville, Florida, United States

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Rexahn Investigative Site

Jacksonville, Florida, United States

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Rexahn Investigative Site

Miami Beach, Florida, United States

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Rexahn Investigative Site

Orlando, Florida, United States

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Rexahn Investigative Site

St. Petersburg, Florida, United States

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Rexahn Investigative Site

Tampa, Florida, United States

Site Status

Rexahn Investigative Site -2

Atlanta, Georgia, United States

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Rexahn Investigative Site

Atlanta, Georgia, United States

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Rexahn Investigative Site

Oak Brook, Illinois, United States

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Rexahn Investigative Site

Vernon Hills, Illinois, United States

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Rexahn Investigative Site

Owensboro, Kentucky, United States

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Rexahn Investigative Site

Novi, Michigan, United States

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Rexahn Investigative Site

Las Vegas, Nevada, United States

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Rexahn Investigative site

Cherry Hill, New Jersey, United States

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Rexahn Investigative Site

Albuquerque, New Mexico, United States

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Rexahn Investigative Site

Fresh Meadows, New York, United States

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Rexahn Investigative Site

New York, New York, United States

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Rexahn Investigative Site

Cincinnati, Ohio, United States

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Rexahn Investigative site

Garfield Heights, Ohio, United States

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Rexahn Investigative Site

Oklahoma City, Oklahoma, United States

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Rexahn Investigative site

Allentown, Pennsylvania, United States

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Rexahn Investigative Site

Media, Pennsylvania, United States

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Rexahn Investigative Site

Scranton, Pennsylvania, United States

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Rexahn Investigative Site

Anderson, South Carolina, United States

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Rexahn Investigative Site

Memphis, Tennessee, United States

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Rexahn Investigative Site

Austin, Texas, United States

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Rexahn Investigative site

Dallas, Texas, United States

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Rexahn Investigative Site

Dallas, Texas, United States

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Rexahn Investigative Sites

Lake Jackson, Texas, United States

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Rexahn Investigative Site

San Antonio, Texas, United States

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Rexahn Investigative Site

The Woodlands, Texas, United States

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Rexahn Investigative Site

Orem, Utah, United States

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Rexahn Investigative Site

Richmond, Virginia, United States

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Rexahn Investigative Site (2)

Bellevue, Washington, United States

Site Status

Rexahn Investigative Site

Bellevue, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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2010MDD01

Identifier Type: -

Identifier Source: org_study_id