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Exercise Capacity in Bronchiectasis Resection

NCT ID: NCT01268475

Last Updated: 2010-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-03-31

Brief Summary

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Bronchiectasis can be defined as an abnormal and irreversible dilatation of the bronchial tree due to repeated cycles of inflammation and infection, resulting in progressive loss of lung function. The surgical treatment by pulmonary resection or even lung transplantation is indicated in cases of bronchiectasis primary nonresponsive to appropriate medical treatment, or when associated with serious complications. There are few literature data on the influence of bronchiectasis in exercise capacity, quality of life and functional capacity, and the impact of lung resection in patients with this diagnosis. The primary objective of this study is to evaluate prospectively the impact of lung resection on exercise capacity in patients with clinical and radiological diagnosis of bronchiectasis. The secondary objective of this study is to evaluate the impact of lung resection on quality of life and lung function and to analyze the the presence of predictors of postoperative functional deterioration and the occurrence of complications.

Detailed Description

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Conditions

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Bronchiectasis

Keywords

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Bronchiectasis Quality of Life Respiratory Function Tests Exercise Test

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Clinical and radiographic diagnosis of bronchiectasis;
* Lack of adequate response to clinical treatment after 1 year of follow-up and / or presence of disease complications;
* Agreement to participate of the study by signing of the Informed Consent Term

Exclusion Criteria

* Comorbidities that prevent the patient to undergo general anesthesia;
* Musculoskeletal and/or psychomotor disability to perform pulmonary function tests and cardiopulmonary exercise tests;
* Inability to understand the quality of life questionnaires;
* Age over 90 years or less 18 years.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Sao Paulo

OTHER

Sponsor Role lead

Responsible Party

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Instituto do Coração HCFMUSP

Locations

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University of Sao Paulo Medical School - Heart Institute

São Paulo, São Paulo, Brazil

Site Status RECRUITING

Countries

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Brazil

Central Contacts

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Ricardo Mingarini Terra, MD, PhD

Role: CONTACT

Phone: 55 11 3069597

Email: [email protected]

Facility Contacts

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Ricardo Mingarini Terra, MD, PhD

Role: primary

References

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Mariani AW, Vallilo CC, de Albuquerque ALP, Salge JM, Augusto MC, Suesada MM, Pego-Fernandes PM, Terra RM. Preoperative evaluation for lung resection in patients with bronchiectasis: should we rely on standard lung function evaluation? Eur J Cardiothorac Surg. 2021 Jun 14;59(6):1272-1278. doi: 10.1093/ejcts/ezaa454.

Reference Type DERIVED
PMID: 33491053 (View on PubMed)

Other Identifiers

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CAPPesq 0671/10

Identifier Type: -

Identifier Source: org_study_id