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Effects of Mirror Neurons Stimulation on Motor Skill Rehabilitation in Children With Cerebral Palsy

NCT ID: NCT01267929

Last Updated: 2017-12-18

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2011-10-31

Brief Summary

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This study aimed to develop Video Compact Disc (VCD) program that applying the concept of imitative learning with mirror neurons stimulation on standard rehabilitation technique in children with cerebral palsy. The author will also examine effectiveness of the program by compare the motor function measured by the gross motor function measure (GMFM-66) between conventional physical therapy and the mirror neurons stimulation based VCD program for six months.

Detailed Description

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A randomized controlled trial was performed with thirty children with cerebral palsy recruited from Thammasat University Hospital and Rajanukul institute. Informed consent was obtained from the participants' parents before participation in this study. The participants were randomly assigned according to the randomization list to receive either the mirror neurons stimulation based VCD program and practice at home or conventional physical therapy for six months. The participants in the experiment group received the mirror neurons stimulation based VCD program and practice at home three times a day for six months. Concerning the control group, the participants received conventional physical therapy regularly at the hospital once a week for first two months and twice a month for last four months. Both experimental and control groups were measured their motor functions with gross motor function measure (GMFM-66).

Conditions

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Children With Spastic Diplegia, Between the Ages of 2 to 10 Years Gross Motor Function Classification System (GMFCS) Level I,II and III

Keywords

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Children with cerebral palsy Gross Motor Function Measure Imitative learning Mirror neuron Action observation Conventional physical therapy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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The mirror neurons stimulation based VCD program

The children receive the mirror neurons stimulation based VCD program and practice at home three times a day for six months. The mirror neurons stimulation based VCD program that contained four volumes. The first volume includes activities activities for improving balance in sitting position. The second volume includes activities of sitting to standing. The third volume includes activities for improving balance in standing position. The last one includes activities of sideway walking. The running time of each volume is 30 minutes. The children had been practicing for two weeks per volume. Their parents were trained for practicing their children by VCD program at home and were asked to complete daily record of children's activities. The children were scheduled to meet a pediatric physical therapist once a week to monitor possible side effects.

Group Type EXPERIMENTAL

The mirror neurons stimulation based VCD program

Intervention Type PROCEDURE

The children receive the mirror neurons stimulation based VCD program and practice at home three times a day for six months.

The conventional physical therapy

The children receive manual physical therapy regularly at the hospital once a week for first two months and twice a month for last four months. The conventional physical therapy technique in this study derive from the manual technique including the Bobath concept, stretching exercise and functional training for 30-45 minutes at a time.

Group Type ACTIVE_COMPARATOR

The conventional physical therapy

Intervention Type PROCEDURE

The children were randomly assigned to receive the conventional physical therapy for six months. Both experimental and control groups were measured their motor functions with GMFM-66 by an independent pediatric physical therapist who was blinded for treatment allocation at entry, the second month and the sixth month.

Interventions

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The mirror neurons stimulation based VCD program

The children receive the mirror neurons stimulation based VCD program and practice at home three times a day for six months.

Intervention Type PROCEDURE

The conventional physical therapy

The children were randomly assigned to receive the conventional physical therapy for six months. Both experimental and control groups were measured their motor functions with GMFM-66 by an independent pediatric physical therapist who was blinded for treatment allocation at entry, the second month and the sixth month.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Children with cerebral palsy aged between 2-10 years old
* GMFCS level of one to three
* Able to verbal instruction
* Sitting are performed without assistance
* Standing and walking are performed with adult assistance
* No severe limitation of joint movement

Exclusion Criteria

* The children were received orthopedic intervention or botulinum toxin injection within 6 months
* Seizure
* Other conditions that prevent children from participate in research project
* Severe visual and hearing deficits
Minimum Eligible Age

2 Years

Maximum Eligible Age

10 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Research Council of Thailand

OTHER_GOV

Sponsor Role collaborator

Thammasat University

OTHER

Sponsor Role lead

Responsible Party

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Namfon Mahasup

Ph.D.candidate, Postgraduate Studied Program, faculty of Medicine, Thammasat University

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Assoc.Prof.Paskorn Sritipsukho, MD

Role: STUDY_DIRECTOR

Thailand:Faculty of Medicine Thammasat University

Locations

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Department of Physical therapy, Faculty of Allied Health Sciences Thammasat University

Pathum Thani, , Thailand

Site Status

Countries

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Thailand

Other Identifiers

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MTU-P-1-71/51

Identifier Type: -

Identifier Source: org_study_id