P16 Staining as Prognostic Biomarker in Serous Papillary Endometrial Cancer

NCT ID: NCT01267357

Last Updated: 2010-12-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

62 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-07-31

Brief Summary

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P16 is a tumor suppressor protein implicated in serous papillary endometrial carcinoma. Evidence from previous trials indicates that it may be used as a diagnostic biomarker distinguishing this disease from endometrioid endometrial cancer. Additional evidence points to its prognostic value.

The current study will evaluate p16 both as a diagnostic tool for serous papillary endometrial cancer and as a prognostic biomarker.

following anonymization, histology blocks will be microtomed and stained for P16 and P53 proteins.

Blocks from endometrioid endometrial cancer will be used as a control group.

Detailed Description

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Conditions

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Serous Papillary Endometrial Cancer

Keywords

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Serous Papillary Endometrial Cancer Endometrioid endometrial cancer biomarkers P16 P53 Prognosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Serous papillary endometrial ca patients

30 patients diagnosed with SP endometrial ca

no intervention

Intervention Type OTHER

Endometrioid endometrial ca

32 patients diagnosed with Endometrioid endometrial ca

no intervention

Intervention Type OTHER

Interventions

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no intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* diagnosis of endometrial cancer
* histology block exists in hospital's library

Exclusion Criteria

* none
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Rambam Health Care Campus

OTHER

Sponsor Role lead

Responsible Party

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Rambam Medical Center

Locations

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Rambam Medical Center

Haifa, , Israel

Site Status

Countries

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Israel

Other Identifiers

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230CTIL

Identifier Type: -

Identifier Source: org_study_id