Study of Everolimus and Sorafenib in Patients With Advanced Thyroid Cancer Who Progressed on Sorafenib Alone

NCT ID: NCT01263951

Last Updated: 2021-10-26

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 35 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-11-30
• Study Completion Date: 2022-05-31

Brief Summary

The goal of this study is to determine the effect of combining everolimus and sorafenib in patients with metastatic differentiated thyroid cancer who progressed on sorafenib alone.

Detailed Description

The purpose of this research study is to:

1. Find out if sorafenib and everolimus prevent the growth of tumors that have grown when treated with sorafenib alone

2. Find out how long one might benefit from treatment with sorafenib and everolimus

3. Find out what side effects this drug may cause

4. Measure the amount of sorafenib and everolimus in the blood and see if "markers" can be found to help understand who might benefit from sorafenib and everolimus.

Conditions

Differentiated Thyroid Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Everolimus and sorafenib

All patients will receive everolimus and sorafenib daily.

Group Type: EXPERIMENTAL

Everolimus

Intervention Type: DRUG

One 5 mg. tablet daily.

Sorafenib

Intervention Type: DRUG

200 mg. twice daily.

Interventions

Everolimus

One 5 mg. tablet daily.

Intervention Type: DRUG

Sorafenib

200 mg. twice daily.

Intervention Type: DRUG

Other Intervention Names

Afinitor; Nexavar

Eligibility Criteria

Inclusion Criteria

• Diagnosis of thyroid cancer, that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective.
• All patients will have been required to have had sorafenib for entry and have had documented progression while on previous treatment with sorafenib.
• Measurable disease defined as at least one malignant lesion that can be accurately measured on computerized tomography (CT) and/or magnetic resonance imaging (MRI) scan.
• ECOG performance status < 2.
• Life expectancy greater than 3 months.
• Intellectual, emotional, and physical ability to comply with oral medication.

Exclusion Criteria

• Restrictions regarding certain prior treatments will apply.
• Significant medical disease including: uncontrolled congestive heart failure; active symptoms of coronary artery disease, uncontrolled seizure disorder; active infection; uncontrolled diabetes mellitus; requirement for chronic high dose corticosteroid treatment (Topical or inhaled corticosteroids are allowed); requirement for concurrent immunosuppressive drug(s); active autoimmune disease.
• Organ allografts.
• Known HIV-infection (HIV testing is not required for participation).
• Pregnant or breast feeding. Women of childbearing potential and sexually active males must be advised to take precautions to prevent pregnancy during treatment
• History of second cancer (except adequately treated basal cell or squamous cell skin cancer, in situ treated cervical cancer, colon cancer or melanoma, or any other cancer for which the patient has been disease-free for three or more years).
• Known hypersensitivity to everolimus or other rapamycins (e.g., sirolimus, temsirolimus) or to its excipients
• Use of any experimental therapy within 4 weeks prior to baseline evaluations done prior to enrollment (with the exception of sorafenib which may be continued until treatment start). Therefore, all experimental treatments other than sorafenib must be discontinued 4 weeks prior to baseline studies or enrollment.
• Patients who did not previously tolerate sorafenib at 200 mg once daily are excluded from the study.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 89 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Bayer

INDUSTRY

Sponsor Role: collaborator

Novartis Pharmaceuticals

INDUSTRY

Sponsor Role: collaborator

Thomas Jefferson University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Marcia Brose, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Hospital of the University of Pennsylvania- Abramson Cancer Center

Locations

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Countries

United States

Other Identifiers

812004

Identifier Type: OTHER

Identifier Source: secondary_id

UPCC 19309

Identifier Type: -

Identifier Source: org_study_id