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Study of the Fixation of Various Vectors in PET/CT in Patients With a With Lung Cancer Before and During of CRT or RT

NCT ID: NCT01261585

Last Updated: 2010-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

5 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-12-31

Study Completion Date

2009-12-31

Brief Summary

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Study of the modification of the fixation(binding) of Fluoro-2-deoxy-D-glucose (FDG), fluoro-misonidazole (FMISO) and 3'deoxy-3-fluoro-thymidine deoxy-3-fluoro-thymidine (FLT) measured in tomography by broadcast(emission,issue) of positrons (PET) at patients before and in the course of exclusive radiotherapy or concomitant radiochemotherapy for primitive bronchial cancer.

This protocle allows to study the simultaneous variations of the metabolism, the hypoxie and the cellular proliferation by PET SCAN at 5 patients reached(affected) by a primitive bronchial cancer in the course of exclusive radiotherapy for primitive bronchial cancer not small cell lung.

The investigators are also going to study several scenarii of optimization of the radiotherapy according to the variations of the tumoral metabolism, the hypoxie and the cellular proliferation measured in the course of radiotherapy (theoretical study on console using the scanner and the various examinations).

Detailed Description

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Conditions

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Bronchial Neoplasms Carcinoma, Non-Small-Cell Lung

Keywords

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Positron-Emission Tomography PET Scan FDG FLT FMISO Non-Small-Cell Lung Carcinoma chemo-Radiation Oncology SUV

Study Design

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Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* patients with non-small-cell lung carcinoma hitologicaly proved
* Candidate patients in a treatment with aim guardian by exclusive thoracic radiotherapy or of concomitant radiochemotherapy (tumoral dose superior to 60 Gy) ( n=5 ).
* Measurable tumor according to the criteria of evaluation RECIST

Exclusion Criteria

* Histology other one than primitive bronchial cancer not in small cells lung
* The patients for whom no tumoral target is assessable (forgiveness completes after first chemotherapy, operated patients).
* Patients for whom a radiotherapy with curative aim is not indicated (tumoral extension, metastases, general state, co-morbidity).
* Patient having benefited from an examination PET in the FDG with in more than 4 weeks and for which a new PET in the FDG is not necessary with in the framework of its disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Henri Becquerel

OTHER

Sponsor Role lead

Responsible Party

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Centre Henri Becquerel

Principal Investigators

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GUERNOU Mohamed, MD

Role: PRINCIPAL_INVESTIGATOR

CHBecquerel

VERA Pierre, MD phD

Role: STUDY_DIRECTOR

CHBecquerel

Locations

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Centre Henri Becquerel

Rouen, Hate Normandie, France

Site Status

Countries

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France

References

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Ganem J, Thureau S, Gardin I, Modzelewski R, Hapdey S, Vera P. Delineation of lung cancer with FDG PET/CT during radiation therapy. Radiat Oncol. 2018 Nov 12;13(1):219. doi: 10.1186/s13014-018-1163-2.

Reference Type DERIVED
PMID: 30419929 (View on PubMed)

Calais J, Thureau S, Dubray B, Modzelewski R, Thiberville L, Gardin I, Vera P. Areas of high 18F-FDG uptake on preradiotherapy PET/CT identify preferential sites of local relapse after chemoradiotherapy for non-small cell lung cancer. J Nucl Med. 2015 Feb;56(2):196-203. doi: 10.2967/jnumed.114.144253. Epub 2015 Jan 8.

Reference Type DERIVED
PMID: 25572091 (View on PubMed)

Other Identifiers

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CHB 08-01

Identifier Type: -

Identifier Source: org_study_id