Properties of Dietary Fibre and Energy Intake

NCT ID: NCT01257295

Last Updated: 2011-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

29 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-12-31

Study Completion Date

2011-05-31

Brief Summary

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Dietary fibers likely have a role in body weight management. They may increase satiety and, as a consequence, reduce energy intake during the next meal. There are, however, many different types of dietary fiber, which have diverse physical properties and can therefore impact these outcomes differently. It is, however, unclear whether dietary fibers with different properties lead to differences in energy intake during the next meal. The objective of this study is to study the effect of pectin in 4 different physicochemical states on ad libitum energy intake and possible underlying mechanisms; i.e. gastrointestinal hormones, gastric emptying rate, feelings of satiety and the method of fiber supplementation. We hypothesize that viscous and gelling fibers will reduce ad libitum energy intake compared to low viscous and low gelling fibers.

Detailed Description

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Conditions

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Healthy Male Subjects

Keywords

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dietary fiber energy intake appetite satiety hormones glucose gastric emptying

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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control

No additions of fiber to a breakfast meal

Group Type PLACEBO_COMPARATOR

control: no fiber addition

Intervention Type DIETARY_SUPPLEMENT

liquid breakfast without addition of fiber

low viscous, low gelling

low viscous, low gelling fibre added to breakfast meal

Group Type ACTIVE_COMPARATOR

breakfast with low viscous, low gelling pectin

Intervention Type DIETARY_SUPPLEMENT

10g of low viscous, low gelling pectin dissolved in a liquid breakfast

high viscous, low gelling

high viscous, low gelling fibre added to breakfast meal

Group Type ACTIVE_COMPARATOR

high viscous, low gelling pectin

Intervention Type DIETARY_SUPPLEMENT

10g of high viscous, low gelling pectin dissolved in a liquid breakfast

low viscous, high gelling

low viscous, high gelling fibre added to breakfast meal

Group Type ACTIVE_COMPARATOR

low viscous, high gelling pectin

Intervention Type DIETARY_SUPPLEMENT

10g of low viscous, high gelling pectin dissolved in a liquid breakfast

high viscous, high gelling

high viscous, high gelling fibre added to breakfast meal

Group Type ACTIVE_COMPARATOR

high viscous, high gelling pectin

Intervention Type DIETARY_SUPPLEMENT

10g of high viscous, high gelling pectin dissolved in a liquid breakfast

fibre supplement

high viscous, high gelling fibre is added, not to the breakfast meal, but as supplement

Group Type ACTIVE_COMPARATOR

pectin supplement

Intervention Type DIETARY_SUPPLEMENT

10g of high viscous, high gelling pectin provided as a dietary supplement, a liquid breakfast is served seperately

Interventions

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control: no fiber addition

liquid breakfast without addition of fiber

Intervention Type DIETARY_SUPPLEMENT

breakfast with low viscous, low gelling pectin

10g of low viscous, low gelling pectin dissolved in a liquid breakfast

Intervention Type DIETARY_SUPPLEMENT

high viscous, low gelling pectin

10g of high viscous, low gelling pectin dissolved in a liquid breakfast

Intervention Type DIETARY_SUPPLEMENT

low viscous, high gelling pectin

10g of low viscous, high gelling pectin dissolved in a liquid breakfast

Intervention Type DIETARY_SUPPLEMENT

high viscous, high gelling pectin

10g of high viscous, high gelling pectin dissolved in a liquid breakfast

Intervention Type DIETARY_SUPPLEMENT

pectin supplement

10g of high viscous, high gelling pectin provided as a dietary supplement, a liquid breakfast is served seperately

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Age 18-30 year
* BMI 18.5-25 kg/m2
* Healthy as judged by the participant

Exclusion Criteria

* Females
* Weight loss or weight gain of more than 5 kg during the last 2 months
* Using an energy restricted diet during the last 2 months
* Lack of appetite for any reason
* Restrained eater: \>2.89, measured by DEBQ (35).
* Smoking
* Heavy alcohol use: \>5 drinks/day (36).
* Reported stomach or bowel disease
* Reported diabetes
* Reported thyroid disease or any other endocrine disorder
* Reported intolerance for pectin, bread, gluten, dairy or not liking of the research foods
* Anemia: Hb\<8.0 mmol/l
* Fasting glucose levels \>5.8 mmol/l
* Blood donation from 6 weeks prior to the study until the end of the study
* Experienced any problems with drawing blood in the past
* Antecubital veins not considered suitable for blood drawing by means of a catheter
* Thesis students or employees of the division of Human Nutrition
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Wageningen University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Edith Feskens, PHd

Role: PRINCIPAL_INVESTIGATOR

Wageningen University

Locations

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Wageningen University

Wageningen, , Netherlands

Site Status

Countries

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Netherlands

Other Identifiers

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METC-10/22

Identifier Type: -

Identifier Source: org_study_id