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Long-term Caloric Restriction and Cellular Aging Markers

NCT ID: NCT01256840

Last Updated: 2017-10-13

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

71 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-12-31

Study Completion Date

2014-08-31

Brief Summary

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The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.

Detailed Description

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Conditions

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Aging

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Calorie Restricting Group

No interventions assigned to this group

Normal-eating controls

No interventions assigned to this group

Obese comparison group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Calorie restricting group: Self-reported caloric restriction for at least two years
* Calorie restriction group: BMI below 23
* Normal eating control: Normal eating (no history of caloric restriction) for two years
* Normal eating control: BMI below 30
* Obese comparison group: BMI above 30
* Obese comparison group: Normal eating (no history of caloric restriction) for two years

Exclusion Criteria

* Regular smoker for the past six months
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Robert Wood Johnson Foundation

OTHER

Sponsor Role collaborator

University of California, San Francisco

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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A. Janet Tomiyama, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of California, San Francisco

Locations

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University of California

San Francisco, California, United States

Site Status

Countries

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United States

References

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Incollingo Belsky AC, Epel ES, Tomiyama AJ. Clues to maintaining calorie restriction? Psychosocial profiles of successful long-term restrictors. Appetite. 2014 Aug;79:106-12. doi: 10.1016/j.appet.2014.04.006. Epub 2014 Apr 18.

Reference Type BACKGROUND
PMID: 24747211 (View on PubMed)

Tomiyama AJ, Milush JM, Lin J, Flynn JM, Kapahi P, Verdin E, Sinclair E, Melov S, Epel ES. Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study. Nutr Healthy Aging. 2017 Mar 31;4(2):147-156. doi: 10.3233/NHA-160017.

Reference Type BACKGROUND
PMID: 28447069 (View on PubMed)

Other Identifiers

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UCSF-CHR-10-01323

Identifier Type: -

Identifier Source: org_study_id